Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1026 to 1050 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
648 decreased cell activation (GO:0001775) 1197: Activation, Fibroblasts
649 decreased macrophage activation (GO:0042116) 1198: Activation, Macrophages
650 increased angiogenesis (GO:0001525) 1213: Increased, Angiogenesis
651 abnormal gene expression (GO:0010467) 1239: Altered, Gene Expression
653 increased cell motility (GO:0048870) 1241: Increased, Motility
654 increased second-messenger-mediated signaling (GO:0019932) 1242: Increased, Second Messenger Production
657 increased offspring quantity (VT:1000189) 1208: Increased, Male offspring
661 abnormal DNA topoisomerase II activity (GO:0061505) 1252: Binding to (interferes with) topoisomerase II enzyme
662 occurrence Translocation, Genetic (MESH:D014178) 1253: MLL chromosomal translocation
663 abnormal cellular component organization (GO:0016043) 1258: Decompartmentalization
665 abnormal plasma membrane organization (GO:0007009) 1259: narcosis
684 abnormal embryo development (GO:0009790) 1295: Defect of Embryogenesis
694 increased cell activation involved in immune response (GO:0002263) 1492: Tissue resident cell activation
695 increased acute inflammatory response (GO:0002526) 1493: Increased Pro-inflammatory mediators
705 decreased fatty acid beta-oxidation (GO:0006635) 1528: Fatty Acid Beta Oxidation, Decreased
713 decreased abnormal circulating hormone level (MP:0005418) None
714 increased cellular response to oxidative stress (GO:0034599) 1394: Induction, persistent proliferation/sustained proliferation
719 increased hypoxia-inducible factor-1alpha signaling pathway (GO:0097411) None
970 increased increased apoptosis (MP:0006042) 1513: General Apoptosis
973 abnormal animal organ development (GO:0048513) 1616: Malformation, cryptorchidism - maldescended testis
975 disrupted peroxisome proliferator activated receptor signaling pathway (GO:0035357) 2227: Disrupted PPAR isoform nuclear signaling
976 disrupted regulation of gene expression (GO:0010468) 2224: Dysregulation of transcriptional expression within PPAR signaling network
977 disrupted lipid storage (GO:0019915) 2225: Disrupted Lipid Storage
985 disrupted voltage-gated sodium channel activity (GO:0005248) 1353: Binding to voltage-gated sodium channel
987 decreased sodium:potassium-exchanging ATPase activity (GO:0005391) None