Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1051 to 1075 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
981 morphological change abnormal excitatory postsynaptic current amplitude (MP:0011267) dendritic spine membrane (GO:0032591) 388: Overactivation, NMDARs
11 occurrence Parkinsonian disorders (MESH:D020734) 896: Parkinsonian motor deficits
50 occurrence membrane depolarization (GO:0051899) 616: Occurrence, A paroxysmal depolarizing shift
52 occurrence excitatory postsynaptic potential (GO:0060079) 682: Generation, Amplified excitatory postsynaptic potential (EPSP)
53 occurrence seizures (NBO:0000025) 613: Occurrence, Epileptic seizure
84 occurrence protein binding (GO:0005515) Selenium-Binding Proteins (MESH:D051137) 261: Binding, SH-/selen-proteins
87 occurrence oxidative stress (MP:0003674) None
129 occurrence cholestasis (MESH:D002779)
156 occurrence Cyanosis (MESH:D003490) 321: N/A, Cyanosis occurs
178 occurrence fatty liver (MESH:D005234) 345: N/A, Liver Steatosis
192 occurrence liver fibrosis (MP:0003333) liver (UBERON:0002107)
208 occurrence Liver Diseases (MESH:D008107) 139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects
260 occurrence inflammatory response (GO:0006954) 486: systemic inflammation leading to hepatic steatosis
442 occurrence toxicity (MESH:Q000633) kidney (UBERON:0002113) 814: Occurrence, Kidney toxicity
443 occurrence autophagic cell death (GO:0048102) renal tubule (UBERON:0009773) 818: Occurrence, Cytoplasmic vacuolization (Renal tubule)
444 occurrence Dilatation (MESH:D004106) renal tubule (UBERON:0009773) 823: Occurrence, Cystic dilatation (renal tubule)
445 occurrence podocyte vacuolization (MP:0011899) 824: Occurrence, Cytoplasmic vacuolization (podocyte)
447 occurrence Mallory bodies (MP:0014045) 839: Formation, Mallory body
450 occurrence autophagic cell death (GO:0048102)
466 occurrence renal tubular necrosis (MP:0004154) 1097: Occurrence, renal proximal tubular necrosis
470 occurrence organelle disassembly (GO:1903008) lysosome (GO:0005764) 898: Disruption, Lysosome
471 occurrence liver inflammation (MP:0001860) 902: Inflammation, Liver
473 occurrence epidermal growth factor-activated receptor activity (GO:0005006) epidermal growth factor receptor (PR:000006933) 941: Activation, EGFR
475 occurrence transdifferentiation (GO:0060290) ciliated epithelial cell (CL:0000067) 919: Occurrence, Transdifferentiation of ciliated epithelial cells
476 occurrence Metaplasia (MESH:D008679) goblet cell (CL:0000160) 920: Occurrence, Metaplasia of goblet cells