Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1051 to 1075 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
313 increased Stress, Physiological (MESH:D013312)
990 occurrence Stress, Physiological (MESH:D013312) heart (UBERON:0000948) None
1019 increased Stress, Physiological (MESH:D013312) heart (UBERON:0000948) 2239: Increased, Cardiac stress
916 decreased succinate dehydrogenase activity (GO:0000104) 2118: Succinate dehydrogenase, inhibited
918 decreased succinate metabolic process (GO:0006105) succinate dehydrogenase complex (GO:0045281) 2118: Succinate dehydrogenase, inhibited
1012 decreased sulfotransferase activity (GO:0008146) estrogen sulfotransferase (PR:000032783) 2155: Inhibition of Sulfotransferase E1 (SULT1E1)
953 occurrence suppression by virus of host cytokine production (GO:0046775) 2180: Immune mechanisms antagonized by viral proteins
70 increased suppression of host defenses (GO:0044414) immune system (UBERON:0002405) 403: Suppression, Immune system
523 decreased survival (MESH:D013534) None
522 decreased swim bladder inflation (GO:0048798) posterior chamber swim bladder (UBERON:2001278) 1004: Reduced, Posterior swim bladder inflation
524 decreased swim bladder inflation (GO:0048798) anterior chamber swim bladder (UBERON:2001277) 1007: Reduced, Anterior swim bladder inflation
62 decreased synapse assembly (GO:0007416) synapse (GO:0045202) 385: Decrease of synaptogenesis
63 decreased synaptic signaling (GO:0099536)
568 increased synaptic transmission, dopaminergic (GO:0001963) dopaminergic neuron (CL:0000700) 1083: Decreased, Dopaminergic activity
395 increased synaptic transmission, dopaminergic (GO:0001963) 746: Increase, Dopaminergic activity
821 increased synaptic transmission, glutamatergic (GO:0035249) None
822 increased synaptic transmission, glutamatergic (GO:0035249) glutamate(1-) (CHEBI:14321) None
823 increased synaptic transmission, glutamatergic (GO:0035249) L-glutamate(1-) (CHEBI:29985) 1350: Increased, glutamate
203 increased T cell activation (GO:0042110) T cell (CL:0000084) 272: Activation/Proliferation, T-cells
746 decreased T cell activation involved in immune response (GO:0002286) 1719: Impairment of T-cell dependent antibody response
903 decreased T cell activation involved in immune response (GO:0002286) T cell (CL:0000084) 1702: Suppression of T cell activation
1041 increased T cell activation involved in immune response (GO:0002286) T cell (CL:0000084) None
1057 occurrence T cell activation involved in immune response (GO:0002286) T cell (CL:0000084) 2260: Gluten-reactive CD4+ T cells, activation
1042 increased T cell migration (GO:0072678) T cell (CL:0000084) None
1054 occurrence T cell migration (GO:0072678) T cell (CL:0000084) 2275: Gluten reactive adaptive T-cells with antigen presenting cells, co-localization