Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1051 to 1075 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1088 decreased decreased neurotransmitter release (MP:0003990) CNS neuron (sensu Vertebrata) (CL:0000117) 1944: Synaptic dysfunction
1090 decreased response to odorant (GO:1990834) Nose (FMA:46472) 2317: Loss of olfactory function
1093 decreased androgen receptor signaling pathway (GO:0030521) androgen receptor (PR:000004191) None
1094 decreased ovarian follicle development (GO:0001541) granulosa cell (CL:0000501) 1800: Granulosa cell proliferation of gonadotropin-independent follicles, Reduced
1097 decreased Dementia (HP:0000726) drebrin (PR:000006296) 2242: Abnormality, dendritic spine morphology
1098 decreased long term synaptic depression (GO:0060292) drebrin (PR:000006296) 2242: Abnormality, dendritic spine morphology
1101 decreased dendritic spine morphogenesis (GO:0060997) actin cytoskeleton (GO:0015629) 2078: Loss of drebrin
1110 decreased cellular response to oxidative stress (GO:0034599) 1869: Diminished protective oxidative stress response
1113 decreased G-protein coupled receptor signaling pathway (GO:0007186) alpha-1A adrenergic receptor (PR:000001183) 2370: Agonism binding, α1-Adrenoreceptor
1115 decreased Decreased activity of mitochondrial complex III (HP:0011924) mitochondrial respiratory chain complex III (GO:0005750) 1542: Inhibition, Mitochondrial complex III
1117 decreased Decreased circulating gonadotropin level (HP:0030339) circulatory system (UBERON:0001009) 1986: Decreased, Gonadotropins
1120 decreased neurotransmitter secretion (GO:0007269) Metastin (CHEBI:80304) 968: Decreased, release of kisspeptin from anteroventral periventricular nucleus (AVPV) neurons
1123 decreased regulation of vascular permeability (GO:0043114) None
1125 decreased mRNA transcription (GO:0009299) undifferentiated genital tubercle (UBERON:0005876) None
1126 decreased protein import into nucleus, translocation (GO:0000060) androgen receptor (PR:000004191) 2393: Androgen receptor nuclear transcriptional activity in genital-tubercle tissues, reduced
1127 decreased regulation of DNA binding (GO:0051101) androgen (CHEBI:50113) 2393: Androgen receptor nuclear transcriptional activity in genital-tubercle tissues, reduced
1128 decreased mesenchymal-epithelial cell signaling (GO:0060638) fibroblast growth factor receptor 2 (PR:000001449) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1129 decreased mesenchymal-epithelial cell signaling (GO:0060638) fibroblast growth factor 10 (PR:000007480) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1130 decreased fibroblast growth factor 10 (PR:000007480) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1131 decreased fibroblast growth factor 2 (PR:000007489) None
1132 decreased cell activation (GO:0001775) fibroblast growth factor 2 (PR:000007489) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1136 decreased neuropeptide signaling pathway (GO:0007218) Metastin (CHEBI:80304) None
98 arrested developmental process (GO:0032502) male reproductive organ (UBERON:0003135) 240: Feminisation or incomplete development, Primary and accessory male sex organs
1092 arrested androgen receptor signaling pathway (GO:0030521) androgen receptor (PR:000004191) None
1135 arrested delayed balanopreputial separation (MP:0008940) prepuce of penis (UBERON:0001332) 2401: Male preputial separation, failed/delayed