Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1051 to 1075 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
891 decreased secondary palatal shelf (UBERON:0005619) None
899 occurrence Blood vessel (FMA:63183) None
904 increased goblet cell (CL:0000160) 2117: Increase, goblet cell number
906 decreased sonic hedgehog protein (PR:000014841) None
924 functional change blood vessel endothelial cell (CL:0000071) 2096: Occurrence, (Micro)vascular dysfunction
925 functional change pericyte cell (CL:0000669) 2096: Occurrence, (Micro)vascular dysfunction
926 functional change smooth muscle cell (CL:0000192) 2096: Occurrence, (Micro)vascular dysfunction
961 increased hepatocyte (CL:0000182) None
494 functional change nitric oxide synthase, endothelial (PR:000011328) 932: KE4 : Uncoupling, eNOS
504 increased thyroxine (CHEBI:30660)
508 decreased estrogen (CHEBI:50114) None
520 decreased 3,3',5-triiodo-L-thyronine (CHEBI:18258)
535 increased Fibrosarcoma (MESH:D005354) 1035: Increased, Firbrosarcoma
536 increased liposarcoma (MESH:D008080) 1036: Increased, liposarcoma
537 increased hemangiosarcoma (MESH:D006394) 1037: Increased, hemagiosarcoma
543 increased leiomyoma (MESH:D007889) 1044: Promotion, mesovarian leiomyomas
544 decreased estradiol (CHEBI:23965) 1045: Decreased, Ovarian E2
548 increased Granular Cell Tumor (MESH:D016586) 1054: Promotion, ovarian granular cell tumors
549 decreased bile (UBERON:0001970) 1058: Decreased, bile flow
551 increased cholecystokinin (PR:000005110) 1061: prolonged, elevation of serun CCK
556 morphological change Metaplasia (MESH:D008679) None
558 increased adenosquamous carcinoma (MESH:D018196) 1070: Increased, adenosquamous carcinomas of endometrium
561 increased estrogen (CHEBI:50114) 1076: Increased, circulating estrogen levels
562 increased prolactin (PR:000013246) 1077: Increased, prolactin exposure
573 increased mesothelioma (MESH:D008654) None