Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1076 to 1100 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
477 occurrence hyperplasia (MESH:D006965) goblet cell (CL:0000160) 921: Occurrence, Hyperplasia of goblet cells
482 occurrence mucus secretion (GO:0070254) None
576 occurrence ischemia (MESH:D007511) kidney (UBERON:0002113) 1105: Occurrence, renal ischemia
588 occurrence anemia (MP:0001577) 1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
662 occurrence Translocation, Genetic (MESH:D014178) 1253: MLL chromosomal translocation
736 occurrence EEG with focal epileptiform discharges (HP:0011185) neuron part (GO:0097458) None
737 occurrence EEG with focal epileptiform discharges (HP:0011185) neuron (CL:0000540) 1623: Occurrence, Focal Seizure
738 occurrence secondary generalized seizure (NBO:0000703) brain (UBERON:0000955) 1788: Status epilepticus
766 occurrence regulation of response to reactive oxygen species (GO:1901031) reactive oxygen species (CHEBI:26523) 1634: Increase, Oxidative DNA damage
771 occurrence regulation of beta-catenin-TCF complex assembly (GO:1904863) beta-catenin-TCF complex (GO:1990907) 1755: beta-catenin activation
772 occurrence epithelial to mesenchymal transition (GO:0001837) cellular_component (GO:0005575) None
773 occurrence regulation of cellular response to drug (GO:2001038) 1651: Treatment-resistant gastric cancer
802 occurrence Abnormal ciliary motility (HP:0012262) motile cilium (GO:0031514) 1908: Cilia Beat Frequency, Decreased
803 occurrence phosphorylation (GO:0016310) epidermal growth factor receptor (PR:000006933) None
872 occurrence receptor binding (GO:0005102) angiotensin-converting enzyme 2 (PR:000003622) 1739: Binding to ACE2
873 occurrence endocytosis involved in viral entry into host cell (GO:0075509) host cell membrane (GO:0033644) None
874 occurrence protease binding (GO:0002020) transmembrane protease serine 2 (PR:000016456) None
875 occurrence membrane fusion (GO:0061025) host cell membrane (GO:0033644) None
876 occurrence membrane fusion (GO:0061025) transmembrane protease serine 2 (PR:000016456) 1738: SARS-CoV-2 cell entry
877 occurrence endocytosis involved in viral entry into host cell (GO:0075509) cathepsin L1 (human) (PR:P07711) 1738: SARS-CoV-2 cell entry
880 occurrence cellular response to exogenous dsRNA (GO:0071360) RNA viral genome (GO:0019022) 1901: Interferon-I antiviral response, antagonized by SARS-CoV-2
899 occurrence Blood vessel (FMA:63183) None
900 occurrence blood vessel remodeling (GO:0001974) blood vessel (UBERON:0001981) 2069: Occurrence, Abnormal Vascular Remodeling
908 occurrence viral entry into host cell (GO:0046718) viral genome (GO:0019015) 1738: SARS-CoV-2 cell entry
909 occurrence viral entry into host cell (GO:0046718) viral protein (PR:000036197) 1738: SARS-CoV-2 cell entry