Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 1076 to 1100 of 1150 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


275	decreased	receptor transactivation (GO:0035624)	COUP transcription factor 2 (PR:000011405)	2 Events 656: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) 541: Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells
280	decreased	cholesterol biosynthetic process (GO:0006695)	cholesterol (CHEBI:16113)	2 Events 642: Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol 807: Decreased, cholesterol
303	increased	colony collapse (MESH:D056631)		2 Events 563: Death/Failure, Colony 1107: Weakened, Colony
312	increased	increased energy expenditure (MP:0004889)		2 Events 573: Increase, Energetic demands and therefore metabolic stress 1110: Increased, Energetic demands and therefore metabolic stress
313	increased	Stress, Physiological (MESH:D013312)		2 Events 573: Increase, Energetic demands and therefore metabolic stress 1110: Increased, Energetic demands and therefore metabolic stress
324	increased	predatory behavior (GO:0002120)		2 Events 588: Increased, predation 623: Increase, predation
325	decreased	sodium channel inhibitor activity (GO:0019871)	sodium channel protein type 1 subunit alpha (PR:000002095)	2 Events 584: Inhibition, sodium channel 598: modulation, sodium channel
327	decreased	aquatic locomotion (NBO:0000371)		2 Events 586: Reduced, swimming speed 1005: Reduced, Swimming performance
328	decreased	life span trait (VT:0005372)		2 Events 592: Reduced, survival 636: Decreased, survival
346	decreased		prostaglandin F2alpha (CHEBI:15553)	2 Events 671: Reduced, Prostaglandin F2alpha concentration, plasma 1104: Decreased, Prostaglandin F2alpha concentration, plasma
347	decreased	prostaglandin biosynthetic process (GO:0001516)	prostaglandin F2alpha (CHEBI:15553)	2 Events 672: Reduced, Prostaglandin F2alpha synthesis, ovary 681: Decreased, Prostaglandin F2alpha synthesis, ovary
350	decreased	reproduction (GO:0000003)		2 Events 675: Reduced, Reproductive Success 1277: Reproductive failure
385	increased	cell proliferation (GO:0008283)	thyroid follicular cell (CL:0002258)	2 Events 739: Increase, Hypertrophy and proliferation (follicular cell) 1024: Increased, Hypertrophy and proliferation (follicular cell)
386	increased	hypertrophy (MESH:D006984)	thyroid follicular cell (CL:0002258)	2 Events 739: Increase, Hypertrophy and proliferation (follicular cell) 1024: Increased, Hypertrophy and proliferation (follicular cell)
387	increased	hyperplasia (MESH:D006965)	thyroid follicular cell (CL:0002258)	2 Events 740: Increase, Hyperplasia (follicular cells) 1025: Increased, Hyperplasia (follicular cells)
388	increased		Thyroid stimulating hormone (CHEBI:81567)	2 Events 753: Increase, Thyroid-stimulating hormone (TSH) 1023: Increased, Thyroid-stimulating hormone (TSH)
392	increased		Luteinizing hormone (CHEBI:81568)	2 Events 754: Increased, Luteinizing hormone (LH) 791: Increased, Leutinizing hormone (LH)
397	increased	chloride channel activity (GO:0005254)	glutamate-gated chloride channel (fruit fly) (PR:Q94900)	2 Events 760: Activation, Glutamate-gated chloride channel 1018: Activation, Glutamate-gated chloride channels
408	increased	cell proliferation (GO:0008283)	epithelial cell (CL:0000066)	2 Events 781: Increase, Regenerative cell proliferation (forestomach epithelial cells) 870: Increase, Cell Proliferation
426	increased	gene expression (GO:0010467)	hypoxia-inducible factor 1-alpha (PR:000008555)	2 Events 799: Increased, HIF-1 heterodimer 802: Increased, HIF-1 alpha transcription
433	decreased	hormone secretion (GO:0046879)	Luteinizing hormone (CHEBI:81568)	2 Events 531: Decreased, LH Surge 1072: Decreased, LH Surge from anterior pituitary
461	increased	necrotic cell death (GO:0070265)		2 Events 868: Increase, Tissue Degeneration, Necrosis & Atrophy 1263: Necrosis
465	increased		uric acid (CHEBI:27226)	2 Events 1096: Increased, blood uric acid concentration 1102: Occurrence, tophi (urate) deposition
510	decreased	luteinizing hormone secretion (GO:0032275)	Luteinizing hormone (CHEBI:81568)	2 Events 970: Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs 1050: Increased, secretion of LH from anterior pituitary
519	decreased	interleukin-4 production (GO:0032633)	interleukin-4 (PR:000001391)	2 Events 1202: Suppression, IL-2 and IL-4 production 1718: Suppression of IL-4 production