Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1076 to 1100 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
704 decreased testicular atrophy (MP:0003205) Testis (FMA:7210) None
723 increased Testicular atrophy (HP:0000029) Testis (FMA:7210) 1506: Testicular atrophy
274 increased Testicular dysgenesis (HP:0008715)
93 decreased testosterone biosynthetic process (GO:0061370) testosterone (CHEBI:17347)
1028 increased testosterone biosynthetic process (GO:0061370) testosterone (CHEBI:17347) 2272: Testosterone levels, increased
307 abnormal thermoregulation behavior (NBO:0000051) 568: impaired, Hive thermoregulation
214 decreased thyroid hormone generation (GO:0006590) thyroid hormone (CHEBI:60311) 277: Thyroid hormone synthesis, Decreased
1014 decreased thyroid hormone transport (GO:0070327) monocarboxylate transporter 8 (PR:000014950) 2258: Inhibition, monocarboxylate transporter 8 (MCT8)
934 occurrence toll-like receptor 3 signaling pathway (GO:0034138) viral genome (GO:0019015) None
936 decreased toll-like receptor 3 signaling pathway (GO:0034138) viral genome (GO:0019015) None
938 decreased toll-like receptor 3 signaling pathway (GO:0034138) influenzavirus NS gene translation product (PR:000044794) 2180: Immune mechanisms antagonized by viral proteins
870 increased toll-like receptor 4 signaling pathway (GO:0034142) Toll-like receptor 4 (PR:000001155) 1495: Substance interaction with the lung resident cell membrane components
935 occurrence toll-like receptor 7 signaling pathway (GO:0034154) viral genome (GO:0019015) None
937 decreased toll-like receptor 7 signaling pathway (GO:0034154) influenzavirus NS gene translation product (PR:000044794) 2180: Immune mechanisms antagonized by viral proteins
869 increased toll-like receptor signaling pathway (GO:0002224) Toll-like receptor (PR:000001096) 1495: Substance interaction with the lung resident cell membrane components
442 occurrence toxicity (MESH:Q000633) kidney (UBERON:0002113) 814: Occurrence, Kidney toxicity
23 increased transcription corepressor activity (GO:0003714) nuclear receptor corepressor 2 (PR:000011048) 1000: stabilization, PPAR alpha co-repressor
24 increased transcription corepressor activity (GO:0003714) nuclear receptor corepressor 1 (PR:000011047) 1000: stabilization, PPAR alpha co-repressor
789 decreased transcription, DNA-templated (GO:0006351) None
949 occurrence transcription, RNA-templated (GO:0001172) segmented viral genome (GO:0019017) 2192: Influenza A Virus production increased
475 occurrence transdifferentiation (GO:0060290) ciliated epithelial cell (CL:0000067) 919: Occurrence, Transdifferentiation of ciliated epithelial cells
193 increased transforming growth factor beta1 production (GO:0032905) TGF-beta 1 (PR:000000182) 276: Up Regulation, TGFbeta1 expression
790 decreased translation (GO:0006412) None
804 increased translation (GO:0006412) mucin-5AC (PR:000031343) 962: Increase, Mucin production
652 abnormal translation (GO:0006412) protein (PR:000000001) 1240: Altered, Protein Production