Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1076 to 1100 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
377 abnormal regulation of gene expression (GO:0010468) 1214: Altered gene expression specific to CAR activation, Hepatocytes
427 abnormal signaling (GO:0023052) hypoxia-inducible factor 1-alpha (PR:000008555) 801: modulation, Unknown
490 abnormal vasodilation (GO:0042311) blood vessel (UBERON:0001981) 937: KE7 : Impaired, Vasodilation
491 abnormal antioxidant activity (GO:0016209) glutathione (CHEBI:16856) 926: Oxidation, Glutathione (To be considered with MIE)
495 abnormal cardiovascular system development (GO:0072358) cardiovascular system (UBERON:0004535) 317: Altered, Cardiovascular development/function
511 abnormal ovulation cycle (GO:0042698) 971: Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation
550 abnormal lipid metabolic process (GO:0006629) 1060: Alteration, lipid metabolism
578 abnormal role (MESH:D012380) 1108: Abnormal, Role change within caste
580 abnormal hemostasis (GO:0007599) 1122: Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis
581 abnormal wound healing (GO:0042060) 1130: Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage)
587 abnormal cellular detoxification (GO:1990748) 1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
591 abnormal vitamin K metabolic process (GO:0042373) vitamin K (CHEBI:28384) 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
601 abnormal post-translational protein modification (GO:0043687) osteocalcin (PR:000030444) 1169: Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
651 abnormal gene expression (GO:0010467) 1239: Altered, Gene Expression
652 abnormal translation (GO:0006412) protein (PR:000000001) 1240: Altered, Protein Production
660 abnormal Food Chain (MESH:D020387) 1210: Alteration, Food-web structures
661 abnormal DNA topoisomerase II activity (GO:0061505) 1252: Binding to (interferes with) topoisomerase II enzyme
663 abnormal cellular component organization (GO:0016043) 1258: Decompartmentalization
665 abnormal plasma membrane organization (GO:0007009) 1259: narcosis
679 abnormal cholesterol (CHEBI:16113) 1289: Perturbation of cholesterol
680 abnormal glutathione (CHEBI:16856) 1290: Glutathione homeostasis
683 abnormal signaling (GO:0023052) Wnt signalosome (GO:1990909) 1294: Inhibition, Wnt pathway
684 abnormal embryo development (GO:0009790) 1295: Defect of Embryogenesis
708 abnormal chemical synaptic transmission (GO:0007268) synapse (GO:0045202) 758: Hippocampal Physiology, Altered
733 abnormal Abnormal spermatogenesis (HP:0008669) Mature sperm cell (FMA:67338) 1758: Impaired, Spermatogenesis