Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1076 to 1100 of 1150 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
829 increased Increased inflammatory response (HP:0012649) interleukin-1 beta (PR:000001136) None
840 increased luteinizing hormone signaling pathway (GO:0042700) None
841 increased increased luteinizing hormone level (MP:0005133) steroidogenic factor 1 (PR:000011411) None
844 increased StAR-related lipid transfer protein 4 (human) (PR:Q96DR4) None
848 increased transmembrane protease serine 2 (human) (PR:O15393) None
849 increased neuropilin binding (GO:0038191) neuropilin-1 (PR:000001900) None
850 increased protease binding (GO:0002020) transmembrane protease serine 2 (human) (PR:O15393) None
852 increased Cytokine (FMA:84050) None
859 increased neutrophil activation (GO:0042119) neutrophil (CL:0000775) None
873 occurrence endocytosis involved in viral entry into host cell (GO:0075509) host cell membrane (GO:0033644) None
874 occurrence protease binding (GO:0002020) transmembrane protease serine 2 (PR:000016456) None
875 occurrence membrane fusion (GO:0061025) host cell membrane (GO:0033644) None
881 decreased receptor antagonist activity (GO:0048019) smoothened homolog (human) (PR:Q99835) None
882 decreased smoothened (PR:000015288) None
884 decreased protein import into nucleus, translocation (GO:0000060) zinc finger protein GLI1 (human) (PR:P08151) None
891 decreased secondary palatal shelf (UBERON:0005619) None
892 decreased palatal shelves fail to meet at midline (MP:0009888) primary palate (UBERON:0005620) None
893 decreased abnormal palatal shelf fusion at midline (MP:0009887) secondary palate (UBERON:0001716) None
896 decreased second-messenger-mediated signaling (GO:0019932) None
899 occurrence Blood vessel (FMA:63183) None
906 decreased sonic hedgehog protein (PR:000014841) None
913 decreased fibrinolysis (GO:0042730) Fibrin (CHEBI:5054) None
929 occurrence receptor-mediated endocytosis (GO:0006898) clathrin-coated vesicle membrane (GO:0030665) None
933 occurrence inhibition of host DNA replication by virus (GO:0098673) interferon regulatory factor 3 complex (GO:0097072) None
934 occurrence toll-like receptor 3 signaling pathway (GO:0034138) viral genome (GO:0019015) None