Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1076 to 1100 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1070 disrupted glucose metabolic process (GO:0006006) 2300: Disruption, Glucolipid metabolism
1071 disrupted abnormal lipid metabolism (MP:0013245) 2300: Disruption, Glucolipid metabolism
1072 abnormal behavior (GO:0007610) 2301: Abnormal, Behavior
1100 increased NMDA glutamate receptor activity (GO:0004972) None
1110 decreased cellular response to oxidative stress (GO:0034599) 1869: Diminished protective oxidative stress response
1114 increased peptide biosynthetic process (GO:0043043) 2371: Increased cortisol
1118 increased prolonged estrous cycle (MP:0009006) 1075: prolonged, estrus cycle
1119 increased prolonged estrus (MP:0009017) 1075: prolonged, estrus cycle
1123 decreased regulation of vascular permeability (GO:0043114) None
1124 increased regulation of vascular permeability (GO:0043114) 2384: Decrease, Vascular integrity
1143 increased female gonad development (GO:0008585) None
1146 increased Hepatic bridging fibrosis (HP:0012852) 2414: COL3A1 Signaling Pathway
1147 increased protein oxidation (GO:0018158) 1767: Increase, Protein oxidation
726 decreased androgen biosynthetic process (GO:0006702) None
742 delayed metamorphosis (GO:0007552) 1101: Altered, Amphibian metamorphosis
743 decreased regulation of binding (GO:0051098) None
744 decreased protein dephosphorylation (GO:0006470) None
746 decreased T cell activation involved in immune response (GO:0002286) 1719: Impairment of T-cell dependent antibody response
750 decreased ecdysis, chitin-based cuticle (GO:0018990) 1524: Increase, Premature molting
751 decreased chitin synthase activity (GO:0004100) 1522: Inhibition, Chitin synthase 1
755 increased viral RNA genome replication (GO:0039694) None
758 increased regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) 1172: Increased activation, Nuclear factor kappa B (NF-kB)
760 increased viral RNA genome packaging (GO:0019074) None
767 increased endocytosis involved in viral entry into host cell (GO:0075509) None
768 increased protease binding (GO:0002020) None