Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1076 to 1100 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
575 increased 3,3',5-triiodo-L-thyronine (CHEBI:18258) 1116: Decreased, Triiodothyronine (T3) in tissues
577 increased Viral load (MESH:D019562) 1109: Increased, Deformed Wing Virus levels
579 increased reactive oxygen species (CHEBI:26523) None
589 decreased blood coagulation factors (MESH:D001779) 1133: Hemostasis, Depletion from blood of fully functional carboxylated clotting factors
596 functional change organ (UBERON:0000062) 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
612 increased population of organisms (PCO:0000001) 1164: Increased, Population
613 premature spawning (MESH:C82476) 1255: induced spawning
619 increased cough (MESH:D003371)
620 increased Respiratory Hypersensitivity (MESH:D012130) 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
621 increased Dyspnea (MESH:D004417) 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
644 pathological Breast Neoplasms (MESH:D001943) 1193: N/A, Breast Cancer
645 functional change deoxyribonucleic acid (CHEBI:16991) 1194: Increase, DNA damage
646 morphological change extracellular matrix (GO:0031012) 1195: modulation, Extracellular Matrix Composition
647 increased epithelial cell (CL:0000066) 1196: Increased, Invasion
658 increased male organism (UBERON:0003101) 1208: Increased, Male offspring
659 increased male reproductive organ (UBERON:0003135) 1209: Induction, Male reproductive tract
660 abnormal Food Chain (MESH:D020387) 1210: Alteration, Food-web structures
679 abnormal cholesterol (CHEBI:16113) 1289: Perturbation of cholesterol
680 abnormal glutathione (CHEBI:16856) 1290: Glutathione homeostasis
696 decreased vascular endothelial growth factor A (PR:000017284) None
703 decreased spermatocyte (CL:0000017) 1515: Spermatocyte depletion
721 increased DNA molecule region (FMA:84119) None
722 disrupted tubulin complex (GO:0045298) 718: Binding, Tubulin
984 disrupted synapse (GO:0045202) 2005: Altered neurotransmission in development
992 increased estradiol (CHEBI:23965) 2251: Estradiol availability, increased