Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1101 to 1125 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
944 occurrence clathrin-dependent endocytosis (GO:0072583) None
945 occurrence vesicle targeting, plasma membrane to endosome (GO:0048201) None
946 occurrence pH reduction (GO:0045851) endosome (GO:0005768) None
947 occurrence membrane fusion (GO:0061025) influenzavirus hemagglutinin (PR:000049750) None
950 occurrence nuclear export (GO:0051168) viral genome (GO:0019015) None
961 increased hepatocyte (CL:0000182) None
965 decreased hormone biosynthetic process (GO:0042446) None
969 increased specification of animal organ position (GO:0010159) urethral opening (UBERON:0010418) None
971 increased gene expression (GO:0010467) lipid (CHEBI:18059) None
972 abnormal specification of animal organ position (GO:0010159) urethral opening (UBERON:0010418) None
982 decreased impaired synaptic plasticity (MP:0001900) actin cytoskeleton of dendritic spine (GO:0098938) None
987 decreased sodium:potassium-exchanging ATPase activity (GO:0005391) None
988 decreased import into cell (GO:0098657) sodium atom (CHEBI:26708) None
990 occurrence Stress, Physiological (MESH:D013312) heart (UBERON:0000948) None
1011 increased chromosome (GO:0005694) None
1015 decreased regulation of body fluid levels (GO:0050878) blood plasma (UBERON:0001969) None
1024 decreased decreased circulating total protein level (MP:0005567) None
1025 increased increased circulating total protein level (MP:0005568) None
1027 increased increased circulating LDL cholesterol level (MP:0000182) blood plasma (UBERON:0001969) None
1029 increased hormone biosynthetic process (GO:0042446) 17beta-hydroxy-5alpha-androstan-3-one (CHEBI:16330) None
1032 increased aromatase (PR:000006100) None
1034 increased antigen presentation trait (VT:0001835) Human leukocyte antigen complex (FMA:84795) None
1035 increased alpha-beta T cell receptor complex (GO:0042105) None
1036 increased gene conversion (GO:0035822) alpha-beta T cell receptor complex (GO:0042105) None
1037 increased gene conversion of immunoglobulin genes (GO:0002206) B cell receptor complex (GO:0019815) None