Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1101 to 1125 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
782 increased increased vascular permeability (MP:0003070) 1867: Bradykinin system, hyperactivated
783 increased vasodilation (GO:0042311) 1867: Bradykinin system, hyperactivated
784 increased vascular inflammation (MP:0001863) 1867: Bradykinin system, hyperactivated
789 decreased transcription, DNA-templated (GO:0006351) None
790 decreased translation (GO:0006412) None
791 decreased chloride channel activity (GO:0005254) 1906: Cystic Fibrosis Transmembrane Regulator Function, Decreased
792 decreased epithelial cilium movement (GO:0003351) None
793 decreased regulation of cilium movement (GO:0003352) None
794 decreased mucociliary clearance trait (VT:0001947) 1909: Mucociliary Clearance, Decreased
821 increased synaptic transmission, glutamatergic (GO:0035249) None
824 increased viral release from host cell (GO:0019076) 1939: Viral infection and host-to-host transmission, proliferated
825 abnormal otic vesicle formation (GO:0030916) 1930: altered, inner ear development
826 increased chronic inflammatory response (GO:0002544) 1868: Hyperinflammation
830 increased regulation of chronic inflammatory response (GO:0002676) 1868: Hyperinflammation
834 increased Increased inflammatory response (HP:0012649) 1868: Hyperinflammation
836 increased lactate dehydrogenase activity (GO:0004457) 1868: Hyperinflammation
840 increased luteinizing hormone signaling pathway (GO:0042700) None
851 disrupted action potential (GO:0001508) 1983: Disruption, action potential generation
855 increased complement activation (GO:0006956) 1496: Increased, secretion of proinflammatory mediators
861 increased mutation (MESH:D009154) 1669: Increased, DNA damage and mutation
868 increased pattern recognition receptor signaling pathway (GO:0002221) 1495: Substance interaction with the lung resident cell membrane components
887 increased gene expression (GO:0010467)
888 decreased gene expression (GO:0010467)
894 increased Cleft palate (HP:0000175) 2042: Increase, Orofacial clefting
895 increased cleft upper lip (MP:0005170) 2042: Increase, Orofacial clefting