Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1126 to 1146 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
956 occurrence viral budding from plasma membrane (GO:0046761) 2193: Influenza A Virus (IAV) budding
908 occurrence viral entry into host cell (GO:0046718) viral genome (GO:0019015) 1738: SARS-CoV-2 cell entry
909 occurrence viral entry into host cell (GO:0046718) viral protein (PR:000036197) 1738: SARS-CoV-2 cell entry
951 occurrence viral mRNA export from host cell nucleus (GO:0046784) 2192: Influenza A Virus production increased
824 increased viral release from host cell (GO:0019076) 1939: Viral infection and host-to-host transmission, proliferated
760 increased viral RNA genome packaging (GO:0019074) None
761 increased viral RNA genome packaging (GO:0019074) viral assembly compartment (GO:0072516) 1847: Increased SARS-CoV-2 production
755 increased viral RNA genome replication (GO:0039694) None
756 increased viral RNA genome replication (GO:0039694) viral RNA-directed RNA polymerase complex (GO:0031381) 1847: Increased SARS-CoV-2 production
763 increased viral translation (GO:0019081) ssRNA viral genome (GO:0019024) 1847: Increased SARS-CoV-2 production
954 occurrence virus induced gene silencing (GO:0009616) 2180: Immune mechanisms antagonized by viral proteins
952 occurrence virus maturation (GO:0019075) 2192: Influenza A Virus production increased
810 functional change vision trait (VT:0002090) eye (UBERON:0000970) 1643: Altered, Visual function
591 abnormal vitamin K metabolic process (GO:0042373) vitamin K (CHEBI:28384) 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
985 disrupted voltage-gated sodium channel activity (GO:0005248) 1353: Binding to voltage-gated sodium channel
31 decreased weight loss (MP:0001263) None
597 decreased wellness/fitness trait (VT:1000152) 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
725 increased Wnt protein secretion (GO:0061355) protein-serine O-palmitoleoyltransferase porcupine (PR:000030936) 1754: Increase, porcupine-induced Wnt secretion and Wnt signaling activation
97 abnormal Wnt signaling pathway (GO:0016055) Wnt signalosome (GO:1990909) 310: Alteration, Wnt pathway
581 abnormal wound healing (GO:0042060) 1130: Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage)
1085 increased wounding (MP:0013027) Nose (FMA:46472) 2312: Increased, nasal lesions