Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1126 to 1147 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
237 abnormal abnormal neuron morphology (MP:0002882) 851: Decrease of GABAergic interneurons
269 abnormal anatomical structure development (GO:0048856) nervous system (UBERON:0001016) 186: Altered, Neuroanatomy
270 abnormal abnormal nervous system physiology (MP:0003633) 192: Altered, Neurophysiology
279 abnormal fetal proteins (MESH:D005326) 661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
286 abnormal cytoskeleton organization (GO:0007010) Leydig cell (CL:0000178) 649: Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton
288 abnormal glucocorticoid receptor activity (GO:0004883) glucocorticoid receptor (PR:000011406) 651: Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells
289 abnormal regulation of steroid biosynthetic process (GO:0050810) 652: Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells
297 abnormal fertilization envelope (GO:0060387) 534: Altered, Formation of cortical envelope
298 abnormal sperm entry (GO:0035037) 535: Abnormal, Sperm penetration (polyspermy)
302 abnormal foraging behavior (GO:0060756) 560: Abnormal, Foraging activity and behavior
304 abnormal binding (GO:0005488) calcium ion (CHEBI:39124) 1243: Altered, Ca2+-calmodulin activated signal transduction
305 abnormal signaling (GO:0023052) calmodulin (PR:000004978) 1243: Altered, Ca2+-calmodulin activated signal transduction
307 abnormal thermoregulation behavior (NBO:0000051) 568: impaired, Hive thermoregulation
310 abnormal DNA repair (GO:0006281) Mitochondrial deoxyribonucleic acid (FMA:67199) 664: Overwhelmed, Mitochondrial DNA repair mechanisms
317 abnormal developmental process (GO:0032502) 577: impaired, Development
321 abnormal calmodulin binding (GO:0005516) calcium ion (CHEBI:39124) 1243: Altered, Ca2+-calmodulin activated signal transduction
348 abnormal fertility (MESH:D005298) 673: Reduced, Spawning behavior
357 abnormal chromosome segregation (GO:0007059) 696: Increased, Chromosome misseggregation
360 abnormal action potential (GO:0001508) 698: Altered, Action Potential
371 abnormal chromosome movement towards spindle pole (GO:0051305) chromosome (GO:0005694) 752: Altered, Meiotic chromosome dynamics
377 abnormal regulation of gene expression (GO:0010468) 1214: Altered gene expression specific to CAR activation, Hepatocytes
427 abnormal signaling (GO:0023052) hypoxia-inducible factor 1-alpha (PR:000008555) 801: modulation, Unknown