Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1126 to 1150 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
868 increased pattern recognition receptor signaling pathway (GO:0002221) 1495: Substance interaction with the lung resident cell membrane components
887 increased gene expression (GO:0010467)
888 decreased gene expression (GO:0010467)
894 increased Cleft palate (HP:0000175) 2042: Increase, Orofacial clefting
895 increased cleft upper lip (MP:0005170) 2042: Increase, Orofacial clefting
896 decreased second-messenger-mediated signaling (GO:0019932) None
914 decreased fibrinolysis (GO:0042730) 1846: Thrombosis and Disseminated Intravascular Coagulation
916 decreased succinate dehydrogenase activity (GO:0000104) 2118: Succinate dehydrogenase, inhibited
920 increased Insulin resistance (HP:0000855) 2119: Increase, Insulin resistance
927 disrupted intercellular transport (GO:0010496) 2096: Occurrence, (Micro)vascular dysfunction
928 occurrence receptor binding (GO:0005102)
939 decreased sexual reproduction (GO:0019953) 2147: Decreased, Viable Offspring
940 decreased decreased body weight (MP:0001262) 864: Decreased, Body Weight
941 increased acute-phase response (GO:0006953) None
942 increased Atherosclerosis (HP:0002621) 1443: Atherosclerosis
944 occurrence clathrin-dependent endocytosis (GO:0072583) None
945 occurrence vesicle targeting, plasma membrane to endosome (GO:0048201) None
951 occurrence viral mRNA export from host cell nucleus (GO:0046784) 2192: Influenza A Virus production increased
952 occurrence virus maturation (GO:0019075) 2192: Influenza A Virus production increased
953 occurrence suppression by virus of host cytokine production (GO:0046775) 2180: Immune mechanisms antagonized by viral proteins
954 occurrence virus induced gene silencing (GO:0009616) 2180: Immune mechanisms antagonized by viral proteins
955 occurrence modulation by virus of host immune response (GO:0075528) 2180: Immune mechanisms antagonized by viral proteins
956 occurrence viral budding from plasma membrane (GO:0046761) 2193: Influenza A Virus (IAV) budding
957 occurrence transmission of virus (GO:0019089) 2194: Influenza A Virus (IAV) shedding and transmission
960 increased Hepatic steatosis (HP:0001397) 459: Increase, Liver steatosis