Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 76 to 100 of 1146 KECs

ID	Action	Object	Associated Key Events (KEs)


77	increased	atrioventricular block (MESH:D054537)	444: Increased, Atrioventricular block and bradycardia
78	increased	decreased heart rate (MESH:D001919)	444: Increased, Atrioventricular block and bradycardia
115	decreased	Follicle stimulating hormone (CHEBI:81569)	129: Reduction, Gonadotropins, circulating concentrations
428	decreased	mevalonate (CHEBI:25350)	805: Decreased, mevalonate
451	functional change	lysosome (GO:0005764)	831: Disturbance, Lysosomal function
134	decreased	eggshell (UBERON:0005079)	106: Reduction, Eggshell thickness
129	occurrence	cholestasis (MESH:D002779)	2 Events 357: Cholestasis, Pathology 1059: Increased, cholestasis
176	increased	triglyceride (CHEBI:17855)	291: Accumulation, Triglyceride
348	abnormal	fertility (MESH:D005298)	673: Reduced, Spawning behavior
86	decreased	glutathione (CHEBI:16856)	None
135	functional change	eggshell (UBERON:0005079)	119: N/A, Gap
562	increased	prolactin (PR:000013246)	1077: Increased, prolactin exposure
132	decreased	prostaglandin E2 (CHEBI:15551)	2 Events 243: Reduction, Prostaglandin E2 concentration 687: Reduced, Prostaglandin E2 concentration, hypothalamus
208	occurrence	Liver Diseases (MESH:D008107)	139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects
462	increased	Metaplasia (MESH:D008679)	869: Increase, Respiratory or Squamous Metaplasia
179	increased	membrane (GO:0016020)	46: Accumulation, Biological membranes
468	increased	Arrhythmias, Cardiac (MESH:D001145)	1106: Occurrence, cardiac arrhythmia
94	decreased	testosterone (CHEBI:17347)	2 Events 446: Reduction, fetal/adult testosterone 525: Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells
95	morphological change	male reproductive organ (UBERON:0003135)	348: Malformation, Male reproductive tract
467	increased	potassium atom (CHEBI:26216)	1098: Increased, blood potassium concentration
465	increased	uric acid (CHEBI:27226)	2 Events 1096: Increased, blood uric acid concentration 1102: Occurrence, tophi (urate) deposition
548	increased	Granular Cell Tumor (MESH:D016586)	1054: Promotion, ovarian granular cell tumors
117	increased	calcium ion (CHEBI:39124)	50: Increase, Ca++ (intracellular)
100	decreased	fertility (MESH:D005298)	6 Events 337: N/A, Impairment of reproductive capacity 505: Decreased sperm quantity / quality in the adult, Decreased fertility 520: Decreased sperm quantity or quality in the adult, Decreased fertility 527: Decreased, Decreased fecundity 543: Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis 330: Decrease, Fertility
429	decreased	cholesterol (CHEBI:16113)	None