Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 101 to 125 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
102 disrupted protein dimerization activity (GO:0046983) aryl hydrocarbon receptor (PR:000003858) None
103 disrupted protein dimerization activity (GO:0046983) aryl hydrocarbon receptor nuclear translocator (PR:000004303) None
104 morphological change developmental process (GO:0032502) cardiovascular system (UBERON:0004535) None
892 decreased palatal shelves fail to meet at midline (MP:0009888) primary palate (UBERON:0005620) None
884 decreased protein import into nucleus, translocation (GO:0000060) zinc finger protein GLI1 (human) (PR:P08151) None
875 occurrence membrane fusion (GO:0061025) host cell membrane (GO:0033644) None
906 decreased sonic hedgehog protein (PR:000014841) None
821 increased synaptic transmission, glutamatergic (GO:0035249) None
933 occurrence inhibition of host DNA replication by virus (GO:0098673) interferon regulatory factor 3 complex (GO:0097072) None
913 decreased fibrinolysis (GO:0042730) Fibrin (CHEBI:5054) None
941 increased acute-phase response (GO:0006953) None
950 occurrence nuclear export (GO:0051168) viral genome (GO:0019015) None
990 occurrence Stress, Physiological (MESH:D013312) heart (UBERON:0000948) None
946 occurrence pH reduction (GO:0045851) endosome (GO:0005768) None
965 decreased hormone biosynthetic process (GO:0042446) None
987 decreased sodium:potassium-exchanging ATPase activity (GO:0005391) None
972 abnormal specification of animal organ position (GO:0010159) urethral opening (UBERON:0010418) None
429 decreased cholesterol (CHEBI:16113) None
1011 increased chromosome (GO:0005694) None
1027 increased increased circulating LDL cholesterol level (MP:0000182) blood plasma (UBERON:0001969) None
1025 increased increased circulating total protein level (MP:0005568) None
418 decreased catalytic activity (GO:0003824) 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (rat) (PR:P31214) None
1032 increased aromatase (PR:000006100) None
1035 increased alpha-beta T cell receptor complex (GO:0042105) None
1029 increased hormone biosynthetic process (GO:0042446) 17beta-hydroxy-5alpha-androstan-3-one (CHEBI:16330) None