Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 126 to 150 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
711 decreased abnormal circulating hormone level (MP:0005418) 3,3',5'-triiodothyronine (CHEBI:28774) None
712 decreased abnormal circulating hormone level (MP:0005418) 3,3',5-triiodo-L-thyronine (CHEBI:18258) None
713 decreased abnormal circulating hormone level (MP:0005418) None
716 decreased hypoxia (MP:0005039) hypoxia-inducible factor 1-alpha (PR:000008555) 1394: Induction, persistent proliferation/sustained proliferation
717 decreased hypoxia (MP:0005039) von Hippel-Lindau disease tumor suppressor (PR:000017294) 1394: Induction, persistent proliferation/sustained proliferation
718 decreased hypoxia-inducible factor-1alpha signaling pathway (GO:0097411) von Hippel-Lindau disease tumor suppressor (PR:000017294) None
720 decreased phagocytosis (GO:0006909) macrophage (CL:0000235) 1668: Frustrated phagocytosis
726 decreased androgen biosynthetic process (GO:0006702) None
727 decreased androgen biosynthetic process (GO:0006702) 11-Keto-testosterone (CHEBI:34133) 1756: Decreased, plasma 11-ketotestosterone level
729 decreased activin receptor signaling pathway (GO:0032924) activin complex (GO:0048180) None
730 decreased activin receptor signaling pathway (GO:0032924) activin receptor complex (GO:0048179) None
731 decreased fin regeneration (GO:0031101) blastemal cell (CL:0000354) 1761: Inhibition, Fin regeneration
734 decreased cholesterol transport (GO:0030301) cholesterol (CHEBI:16113) 807: Decreased, cholesterol
735 decreased cholesterol transport (GO:0030301) cholesteryl ester (CHEBI:17002) 807: Decreased, cholesterol
739 decreased population growth rate (PCO:0000008) population of organisms (PCO:0000001) 360: Decrease, Population growth rate
743 decreased regulation of binding (GO:0051098) None
744 decreased protein dephosphorylation (GO:0006470) None
745 decreased negative regulation of DNA binding (GO:0043392) protein-DNA complex (GO:0032993) 1717: Suppression of STAT5 binding to cytokine gene promoters
746 decreased T cell activation involved in immune response (GO:0002286) 1719: Impairment of T-cell dependent antibody response
747 decreased regulation of binding (GO:0051098) tyrosine-protein kinase JAK3 (PR:000009198) 1715: Inhibition of JAK3
748 decreased protein dephosphorylation (GO:0006470) signal transducer and transcription activator STAT (PR:000001933) 1716: Blockade of STAT5 phosphorylation
749 decreased cuticle development (GO:0042335) cuticle (UBERON:0001002) 1523: Decrease, Cuticular chitin content
750 decreased ecdysis, chitin-based cuticle (GO:0018990) 1524: Increase, Premature molting
751 decreased chitin synthase activity (GO:0004100) 1522: Inhibition, Chitin synthase 1
752 decreased cell proliferation (GO:0008283) cell (GO:0005623) 1821: Decrease, Cell proliferation