Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 126 to 150 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
52 occurrence excitatory postsynaptic potential (GO:0060079) 682: Generation, Amplified excitatory postsynaptic potential (EPSP)
53 occurrence seizures (NBO:0000025) 613: Occurrence, Epileptic seizure
57 increased cell death (GO:0008219)
58 increased neurodegeneration (MP:0002229) 352: N/A, Neurodegeneration
59 decreased learning (GO:0007612) 341: Impairment, Learning and memory
63 decreased synaptic signaling (GO:0099536)
64 decreased memory (GO:0007613) 341: Impairment, Learning and memory
67 decreased cytokine production involved in inflammatory response (GO:0002534) 152: Suppression, Inflammatory cytokines
71 increased Disease Susceptibility (MESH:D004198) 323: Increased, Disease susceptibility
79 increased respiratory distress (MP:0001954) 445: Respiratory distress/arrest
80 increased ataxia (MP:0001393)
81 increased hyperactivity (MP:0001399)
82 increased paralysis (MP:0000753)
83 decreased population growth rate (PCO:0000008)
85 disrupted protein domain specific binding (GO:0019904) 158: N/A, Interferences with SH-/selen-proteins
87 occurrence oxidative stress (MP:0003674) None
88 increased neuron death in response to oxidative stress (GO:0036475) 191: Neuronal dysfunction
105 morphological change abnormal cardiovascular system physiology (MP:0001544) 317: Altered, Cardiovascular development/function
109 decreased egg quantity (VT:1000294)
112 decreased oocyte growth (GO:0001555) 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
113 decreased oocyte development (GO:0048599) 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
122 decreased long-term synaptic potentiation (GO:0060291) 166: Decreased, Long-term potentiation (LTP)
123 increased oxidative stress (MP:0003674)
128 increased inflammatory response (GO:0006954)
136 abnormal multi-organism reproductive process (GO:0044703) 253: N/A, Reproductive failure