Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 126 to 150 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
546 increased hyperplasia (MESH:D006965) stromal cell of ovary (CL:0002132) 1051: Hyperplasia, ovarian stromal cells
674 increased gene expression (GO:0010467) sterol regulatory element-binding protein 2 proteolytic cleavage product (PR:000021564) 1284: Up Regulation, SREBF2
1046 increased increased circulating total protein level (MP:0005568) sterol regulatory element-binding protein 2 (PR:000015612) 2269: Increased, Sterol Regulatory Element Binding Protein 2 (SREBP2) protein expression
172 increased SREBP signaling pathway (GO:0032933) sterol regulatory element-binding protein 1 (PR:000015611)
245 increased signaling (GO:0023052) sterol regulatory element-binding protein 1 (PR:000015611) 457: Activation, SREBF1
841 increased increased luteinizing hormone level (MP:0005133) steroidogenic factor 1 (PR:000011411) None
354 decreased steroid hormone (CHEBI:26764) 691: Reduced, Maturation inducing steroid, plasma
355 decreased steroid hormone receptor activity (GO:0003707) steroid hormone (CHEBI:26764) 692: Reduced, Maturation inducing steroid receptor signalling, oocyte
358 decreased signaling (GO:0023052) steroid hormone (CHEBI:26764) 692: Reduced, Maturation inducing steroid receptor signalling, oocyte
847 increased increased luteinizing hormone level (MP:0005133) StAR-related lipid transfer protein 6 (PR:000015721) 1972: Increased, Steroidogenic acute regulatory protein (StAR)
846 increased increased luteinizing hormone level (MP:0005133) StAR-related lipid transfer protein 5 (PR:000015720) 1972: Increased, Steroidogenic acute regulatory protein (StAR)
844 increased StAR-related lipid transfer protein 4 (human) (PR:Q96DR4) None
845 increased increased luteinizing hormone level (MP:0005133) StAR-related lipid transfer protein 4 (PR:000015719) 1972: Increased, Steroidogenic acute regulatory protein (StAR)
842 increased increased luteinizing hormone level (MP:0005133) StAR-related lipid transfer protein 3 (PR:000015718) 1972: Increased, Steroidogenic acute regulatory protein (StAR)
90 decreased gene expression (GO:0010467) STAR (PR:000015715) 266: Decrease, Steroidogenic acute regulatory protein (STAR)
762 increased mRNA transcription (GO:0009299) ssRNA viral genome (GO:0019024) 1847: Increased SARS-CoV-2 production
763 increased viral translation (GO:0019081) ssRNA viral genome (GO:0019024) 1847: Increased SARS-CoV-2 production
1107 increased Metaplasia (MESH:D008679) Squamous cell (FMA:66769)
374 decreased spindle organization (GO:0007051) spindle (GO:0005819) 721: Disorganization, Meiotic Spindle
703 decreased spermatocyte (CL:0000017) 1515: Spermatocyte depletion
268 morphological change sperm (CL:0000019) 520: Decreased sperm quantity or quality in the adult, Decreased fertility
277 decreased sperm (CL:0000019)
613 premature spawning (MESH:C82476) 1255: induced spawning
906 decreased sonic hedgehog protein (PR:000014841) None
907 decreased second-messenger-mediated signaling (GO:0019932) sonic hedgehog protein (PR:000014841) 2043: Decrease, Sonic Hedgehog second messenger production