Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 151 to 175 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
140 increased Kidney Diseases (MESH:D007674) 252: Increase, Renal pathology due to VTG deposition
141 abnormal reproductive behavior (GO:0019098) 363: Altered, Reproductive behaviour
142 abnormal larval development (GO:0002164)
145 increased heme oxidation (GO:0006788) 213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)
149 increased hemoglobin binding (GO:0030492) 118: Formation, Formation of hemoglobin adducts
152 increased liver vascular congestion (MP:0010019) 246: Increase, RBC congestion in liver
159 decreased Decreased liver function (HP:0001410) 164: Induction, Liver “Dysfunctional” Changes by CGA 330050
161 increased hepatotoxicity (MI:2141) 270: Induction, Sustained Hepatotoxicity
162 increased hepatocyte proliferation (GO:0072574) 269: Induction, Sustained Cell Proliferation
165 increased kidney failure (MP:0003606) 759: Increased, Kidney Failure
190 increased protein alkylation (GO:0008213) 244: Alkylation, Protein
197 increased Respiratory Hypersensitivity (MESH:D012130) 313: Increase, Allergic Respiratory Hypersensitivity Response
199 increased keratinocyte activation (GO:0032980) 826: Activation, Keratinocytes
200 increased cytokine production involved in inflammatory response (GO:0002534) 826: Activation, Keratinocytes
201 increased cell activation (GO:0001775)
202 increased MHC protein complex assembly (GO:0002396) 398: Activation, Dendritic Cells
206 abnormal cellular homeostasis (GO:0019725) 853: Changes/Inhibition, Cellular Homeostasis and Apoptosis
207 decreased apoptotic process (GO:0006915)
215 decreased learning or memory (GO:0007611) 402: Cognitive function, decreased
216 decreased cognition (GO:0050890) 402: Cognitive function, decreased
219 decreased angiogenesis (GO:0001525) 28: Reduction, Angiogenesis
220 abnormal endothelium development (GO:0003158) 110: Impairment, Endothelial network
223 morphological change anatomical structure morphogenesis (GO:0009653) 1001: Increased, Developmental Defects
225 increased metabolic process (GO:0008152) 409: Metabolism of AFB1, Production of Reactive Electrophiles
231 abnormal sex ratio (MESH:D012744) 417: skewed, sex ratio