Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 176 to 200 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
233 increased hemorrhage (MP:0001914)
234 increased Nephropathy (HP:0000112) 422: Increased, nephropathy
237 abnormal abnormal neuron morphology (MP:0002882) 851: Decrease of GABAergic interneurons
488 increased increased systemic vascular resistance (MP:0004878) 951: KE8 : Increase, Vascular Resistance
489 increased hypertension (MP:0000231) 952: Hypertension
496 increased pericardial edema (MP:0001787) 358: Increase, Pericardial edema
497 increased embryonic lethality (MP:0008762) 947: Increase, Early Life Stage Mortality
511 abnormal ovulation cycle (GO:0042698) 971: Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation
514 increased Immunosuppression (MESH:D007165) None
523 decreased survival (MESH:D013534) None
525 decreased sensory perception of sound (GO:0007605) 1008: Reduced, Hearing
527 increased inhibitory postsynaptic potential (GO:0060080) 1012: Increased, Inhibitory postsynaptic potential
531 increased fat cell differentiation (GO:0045444) 1029: Increased, adipogenesis
540 increased relaxation of smooth muscle (GO:0044557) 1040: relaxation, smooth muscle
550 abnormal lipid metabolic process (GO:0006629) 1060: Alteration, lipid metabolism
559 disrupted abnormal ovulation (MP:0001928) 1074: interruption, Ovulation
560 delayed estrus (GO:0060209) None
563 increased mammary gland hyperplasia (MP:0000630) 1078: Hyperplasia, Mammary gland
564 increased abnormal tumor latency (MP:0010307) 1080: Increased, latency period
574 increased metamorphosis (GO:0007552) 1101: Altered, Amphibian metamorphosis
578 abnormal role (MESH:D012380) 1108: Abnormal, Role change within caste
580 abnormal hemostasis (GO:0007599) 1122: Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis
581 abnormal wound healing (GO:0042060) 1130: Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage)
587 abnormal cellular detoxification (GO:1990748) 1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
588 occurrence anemia (MP:0001577) 1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal