Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 201 to 225 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
590 decreased hemostasis (GO:0007599) 1133: Hemostasis, Depletion from blood of fully functional carboxylated clotting factors
594 increased acidosis (MP:0003031) 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
595 increased hypovolemia (MP:0010128) 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
597 decreased wellness/fitness trait (VT:1000152) 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
598 increased oxidative phosphorylation uncoupler activity (GO:0017077) 1138: Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP
599 increased osteoporosis (MP:0000066) 1151: Osteoporosis and vascular calcification, Bone deterioration
611 increased reproductive process (GO:0022414) 1163: Increased, Reproductive Success
622 increased dermatitis (MP:0001194)
624 increased abnormal acute inflammation (MP:0002498) 1225: Immune system inflammation
630 increased immune response (GO:0006955) 1237: Sensitization, Immune system
641 increased endothelial cell proliferation (GO:0001935) 1189: Increased, Proliferation (Endothelial cells)
642 increased endothelial cell migration (GO:0043542) 1190: Increased, Migration (Endothelial Cells)
643 increased signaling (GO:0023052) 1191: Increased, Non-genomic signaling
648 decreased cell activation (GO:0001775) 1197: Activation, Fibroblasts
649 decreased macrophage activation (GO:0042116) 1198: Activation, Macrophages
650 increased angiogenesis (GO:0001525) 1213: Increased, Angiogenesis
651 abnormal gene expression (GO:0010467) 1239: Altered, Gene Expression
653 increased cell motility (GO:0048870) 1241: Increased, Motility
654 increased second-messenger-mediated signaling (GO:0019932) 1242: Increased, Second Messenger Production
657 increased offspring quantity (VT:1000189) 1208: Increased, Male offspring
661 abnormal DNA topoisomerase II activity (GO:0061505) 1252: Binding to (interferes with) topoisomerase II enzyme
662 occurrence Translocation, Genetic (MESH:D014178) 1253: MLL chromosomal translocation
663 abnormal cellular component organization (GO:0016043) 1258: Decompartmentalization
665 abnormal plasma membrane organization (GO:0007009) 1259: narcosis
684 abnormal embryo development (GO:0009790) 1295: Defect of Embryogenesis