Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 201 to 225 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
71 increased Disease Susceptibility (MESH:D004198) 323: Increased, Disease susceptibility
72 increased DNA alkylation (GO:0006305) deoxyribonucleic acid (CHEBI:16991) 97: Alkylation, DNA
73 increased mutation (MESH:D009154) deoxyribonucleic acid (CHEBI:16991)
76 increased acetylcholine (CHEBI:15355) 10: Acetylcholine accumulation in synapses
77 increased atrioventricular block (MESH:D054537) 444: Increased, Atrioventricular block and bradycardia
78 increased decreased heart rate (MESH:D001919) 444: Increased, Atrioventricular block and bradycardia
79 increased respiratory distress (MP:0001954) 445: Respiratory distress/arrest
80 increased ataxia (MP:0001393)
81 increased hyperactivity (MP:0001399)
82 increased paralysis (MP:0000753)
88 increased neuron death in response to oxidative stress (GO:0036475) 191: Neuronal dysfunction
89 increased peroxisome proliferator activated receptor signaling pathway (GO:0035357) peroxisome proliferator-activated receptor alpha (PR:000013056) 227: Activation, PPARĪ±
101 increased aryl hydrocarbon receptor activity (GO:0004874) aryl hydrocarbon receptor (PR:000003858) 18: Activation, AhR
106 increased gene expression (GO:0010467) prostaglandin G/H synthase 2 (PR:000013428) 1269: Increase, COX-2 expression
107 increased androgen receptor activity (GO:0004882) androgen receptor (PR:000004191) 25: Agonism, Androgen receptor
117 increased calcium ion (CHEBI:39124) 50: Increase, Ca++ (intracellular)
120 increased reactive oxygen species biosynthetic process (GO:1903409) reactive oxygen species (CHEBI:26523) 1115: Increase, Reactive oxygen species
123 increased oxidative stress (MP:0003674)
125 increased gene expression (GO:0010467) bile acid receptor (PR:000011396) 288: Activation of specific nuclear receptors, Transcriptional change
126 increased bile (UBERON:0001970) 214: Bile accumulation, Pathological condition
127 increased cytokine secretion (GO:0050663) Cytokine (FMA:84050) 87: Release, Cytokine
128 increased inflammatory response (GO:0006954)
137 increased estrogen receptor activity (GO:0030284) estrogen receptor (PR:000007204)
138 increased vitellogenins (MESH:D014819)
139 increased gene expression (GO:0010467) vitellogenins (MESH:D014819)