Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 201 to 225 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
292 decreased signaling (GO:0023052) proto-oncogene c-Fos (mouse) (PR:P01101) 529: Decreased, GnRH cfos activity
582 decreased carboxylation reaction (MI:1139) prothrombin (PR:000007299) 1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)
725 increased Wnt protein secretion (GO:0061355) protein-serine O-palmitoleoyltransferase porcupine (PR:000030936) 1754: Increase, porcupine-induced Wnt secretion and Wnt signaling activation
745 decreased negative regulation of DNA binding (GO:0043392) protein-DNA complex (GO:0032993) 1717: Suppression of STAT5 binding to cytokine gene promoters
656 increased gene expression (GO:0010467) protein doublesex (fruit fly) (PR:P23023) 1206: Induction, Doublesex1 gene
607 increased signaling (GO:0023052) protein (PR:000000001) 1157: Activation, Hepatic nuclear receptor(s)
633 increased oxidation-reduction process (GO:0055114) protein (PR:000000001) 1238: Activation of oxidative stress pathway
652 abnormal translation (GO:0006412) protein (PR:000000001) 1240: Altered, Protein Production
7 abnormal Proteostasis deficiencies (MESH:D057165) protein (CHEBI:36080) 889: Proteostasis, impaired
106 increased gene expression (GO:0010467) prostaglandin G/H synthase 2 (PR:000013428) 1269: Increase, COX-2 expression
131 decreased prostaglandin-endoperoxide synthase activity (GO:0004666) prostaglandin G/H synthase 2 (PR:000013428) 79: Inhibition, Cyclooxygenase activity
130 decreased prostaglandin-endoperoxide synthase activity (GO:0004666) prostaglandin G/H synthase 1 (PR:000013427)
346 decreased prostaglandin F2alpha (CHEBI:15553)
347 decreased prostaglandin biosynthetic process (GO:0001516) prostaglandin F2alpha (CHEBI:15553)
132 decreased prostaglandin E2 (CHEBI:15551)
263 decreased prostaglandin (CHEBI:26333) 685: Reduced, Prostaglandins, ovary
1049 increased increased circulating total protein level (MP:0005568) proprotein convertase subtilisin/kexin type 9 (PR:000012440) 2276: Increased, protein expression of proprotein convertase subtilisin/kexin type 9 (PCSK9)
425 decreased catalytic activity (GO:0003824) Prolyl hydroxylases (MESH:D064828) 798: Inhibition, Prolyl hydroxylases
565 increased hyperplasia (MESH:D006965) prolactin secreting cell (CL:0000439) 1081: Increased, lactotroph hyperplasia and hypertrophy
566 increased hypertrophy (MESH:D006984) prolactin secreting cell (CL:0000439) 1081: Increased, lactotroph hyperplasia and hypertrophy
562 increased prolactin (PR:000013246) 1077: Increased, prolactin exposure
569 increased prolactin secretion (GO:0070459) prolactin (PR:000013246) 1084: Increased, prolactin secretion
393 decreased Prolactin (CHEBI:81580) 747: Decreased, Prolactin
394 decreased progesterone secretion (GO:0042701) progesterone (CHEBI:17026) 749: Decreased, Progesterone from corpus luteum
1043 increased dendritic cell migration (GO:0036336) professional antigen presenting cell (CL:0000145) None