Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1 to 25 of 1145 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
279 abnormal fetal proteins (MESH:D005326) 661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
44 abnormal chemical synaptic transmission (GO:0007268) None
269 abnormal anatomical structure development (GO:0048856) nervous system (UBERON:0001016) 186: Altered, Neuroanatomy
231 abnormal sex ratio (MESH:D012744) 417: skewed, sex ratio
288 abnormal glucocorticoid receptor activity (GO:0004883) glucocorticoid receptor (PR:000011406) 651: Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells
60 abnormal dendrite morphogenesis (GO:0048813) dendrite (GO:0030425) 382: Aberrant, Dendritic morphology
143 abnormal developmental process (GO:0032502) reproductive organ (UBERON:0003133) 364: Impaired development of, Reproductive organs
142 abnormal larval development (GO:0002164)
237 abnormal abnormal neuron morphology (MP:0002882) 851: Decrease of GABAergic interneurons
209 abnormal cell proliferation (GO:0008283) Liver cell (FMA:63179) 854: Alterations, Cellular proliferation / hyperplasia
42 abnormal regulation of gene expression (GO:0010468) hippocampal formation (UBERON:0002421) 756: Hippocampal gene expression, Altered
29 abnormal ketone body (CHEBI:73693) 862: Not Increased, Circulating Ketone Bodies
180 abnormal plasma membrane (GO:0005886) 169: Disruption, Membrane integrity
141 abnormal reproductive behavior (GO:0019098) 363: Altered, Reproductive behaviour
286 abnormal cytoskeleton organization (GO:0007010) Leydig cell (CL:0000178) 649: Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton
7 abnormal Proteostasis deficiencies (MESH:D057165) protein (CHEBI:36080) 889: Proteostasis, impaired
224 abnormal DNA alkylation (GO:0006305) Nuclear deoxyribonucleic acid (FMA:67194) 373: Formation, Pro-mutagenic DNA Adducts
136 abnormal multi-organism reproductive process (GO:0044703) 253: N/A, Reproductive failure
206 abnormal cellular homeostasis (GO:0019725) 853: Changes/Inhibition, Cellular Homeostasis and Apoptosis
28 abnormal abnormal lipid homeostasis (MP:0002118) 862: Not Increased, Circulating Ketone Bodies
97 abnormal Wnt signaling pathway (GO:0016055) Wnt signalosome (GO:1990909) 310: Alteration, Wnt pathway
222 abnormal capillary plexus (UBERON:0035753) 298: Insufficiency, Vascular
146 abnormal gene expression (GO:0010467) hemoglobin subunit alpha (human) (PR:P69905) 21: Altered regulation, Alpha hemoglobin
220 abnormal endothelium development (GO:0003158) 110: Impairment, Endothelial network
270 abnormal abnormal nervous system physiology (MP:0003633) 192: Altered, Neurophysiology