Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1 to 25 of 1145 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
43 morphological change hippocampal formation (UBERON:0002421) None
31 decreased weight loss (MP:0001263) None
523 decreased survival (MESH:D013534) None
508 decreased estrogen (CHEBI:50114) None
104 morphological change developmental process (GO:0032502) cardiovascular system (UBERON:0004535) None
418 decreased catalytic activity (GO:0003824) 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (rat) (PR:P31214) None
474 decreased epithelial cell apoptotic process (GO:1904019) None
177 functional change mitochondrion disassembly (GO:0061726) mitochondrion (GO:0005739) None
87 occurrence oxidative stress (MP:0003674) None
103 disrupted protein dimerization activity (GO:0046983) aryl hydrocarbon receptor nuclear translocator (PR:000004303) None
61 decreased glutamate secretion, neurotransmission (GO:0061535) glutamate(1-) (CHEBI:14321) None
44 abnormal chemical synaptic transmission (GO:0007268) None
480 increased secretion (GO:0046903) mucin-5AC (PR:000031343) None
514 increased Immunosuppression (MESH:D007165) None
556 morphological change Metaplasia (MESH:D008679) None
365 increased epithelial cell proliferation (GO:0050673) nephron tubule epithelial cell (CL:1000494) None
429 decreased cholesterol (CHEBI:16113) None
86 decreased glutathione (CHEBI:16856) None
102 disrupted protein dimerization activity (GO:0046983) aryl hydrocarbon receptor (PR:000003858) None
560 delayed estrus (GO:0060209) None
36 disrupted ovulation cycle (GO:0042698) None
187 increased fatty liver (MESH:D005234) None
74 functional change DNA repair (GO:0006281) deoxyribonucleic acid (CHEBI:16991) None
509 decreased neurotransmitter secretion (GO:0007269) metastasis-suppressor KiSS-1 (rat) (PR:Q7TSB7) None
482 occurrence mucus secretion (GO:0070254) None