Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1 to 25 of 1145 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
57 increased cell death (GO:0008219)
50 occurrence membrane depolarization (GO:0051899) 616: Occurrence, A paroxysmal depolarizing shift
44 abnormal chemical synaptic transmission (GO:0007268) None
64 decreased memory (GO:0007613) 341: Impairment, Learning and memory
31 decreased weight loss (MP:0001263) None
28 abnormal abnormal lipid homeostasis (MP:0002118) 862: Not Increased, Circulating Ketone Bodies
21 decreased excitatory postsynaptic potential (GO:0060079) 1268: Decrease, Excitatory postsynaptic potential
59 decreased learning (GO:0007612) 341: Impairment, Learning and memory
58 increased neurodegeneration (MP:0002229) 352: N/A, Neurodegeneration
67 decreased cytokine production involved in inflammatory response (GO:0002534) 152: Suppression, Inflammatory cytokines
51 decreased chemical synaptic transmission (GO:0007268) 669: Reduction, Neuronal synaptic inhibition
16 increased mortality (MESH:D009026)
15 increased muscle contraction (GO:0006936)
1 increased cell proliferation (GO:0008283)
13 decreased ecdysis-triggering hormone activity (GO:0008255) 988: Decrease, Circulating ecdysis triggering hormone
52 occurrence excitatory postsynaptic potential (GO:0060079) 682: Generation, Amplified excitatory postsynaptic potential (EPSP)
36 disrupted ovulation cycle (GO:0042698) None
10 increased loss of dopaminergic neurons (MP:0003244) 890: Degeneration of dopaminergic neurons of the nigrostriatal pathway
63 decreased synaptic signaling (GO:0099536)
45 increased cochlear degeneration (MP:0000032) 319: Loss, Cochlear function
27 decreased ketosis (MESH:D007662)
53 occurrence seizures (NBO:0000025) 613: Occurrence, Epileptic seizure
35 decreased fertility (MESH:D005298) 406: decreased, Fertility
3 increased hepatocellular carcinoma (MESH:D006528) 334: Promotion, Hepatocelluar carcinoma
2 increased hyperplasia (MESH:D006965)