Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 1 to 25 of 1145 KECs

ID	Action	Object	Associated Key Events (KEs)


100	decreased	fertility (MESH:D005298)	6 Events 337: N/A, Impairment of reproductive capacity 505: Decreased sperm quantity / quality in the adult, Decreased fertility 520: Decreased sperm quantity or quality in the adult, Decreased fertility 527: Decreased, Decreased fecundity 543: Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis 330: Decrease, Fertility
68	decreased	lymphocyte (CL:0000542)	168: Decreased, Lymphocytes
134	decreased	eggshell (UBERON:0005079)	106: Reduction, Eggshell thickness
29	abnormal	ketone body (CHEBI:73693)	862: Not Increased, Circulating Ketone Bodies
135	functional change	eggshell (UBERON:0005079)	119: N/A, Gap
126	increased	bile (UBERON:0001970)	214: Bile accumulation, Pathological condition
78	increased	decreased heart rate (MESH:D001919)	444: Increased, Atrioventricular block and bradycardia
132	decreased	prostaglandin E2 (CHEBI:15551)	2 Events 243: Reduction, Prostaglandin E2 concentration 687: Reduced, Prostaglandin E2 concentration, hypothalamus
95	morphological change	male reproductive organ (UBERON:0003135)	348: Malformation, Male reproductive tract
121	decreased	nitric oxide (CHEBI:16480)	193: Decreased, Nitric Oxide
118	disrupted	mitochondrial respiratory chain (GO:0005746)	178: Mitochondrial electron transport chain, disrupted
41	decreased	thyroxine (CHEBI:30660)	3 Events 771: Decrease, Serum thyroid hormone (T4/T3) 1022: Decreased, serum T4/T3 1093: Decreased, Thyroxine (T4) in tissues
86	decreased	glutathione (CHEBI:16856)	None
129	occurrence	cholestasis (MESH:D002779)	2 Events 357: Cholestasis, Pathology 1059: Increased, cholestasis
77	increased	atrioventricular block (MESH:D054537)	444: Increased, Atrioventricular block and bradycardia
76	increased	acetylcholine (CHEBI:15355)	10: Acetylcholine accumulation in synapses
11	occurrence	Parkinsonian disorders (MESH:D020734)	896: Parkinsonian motor deficits
117	increased	calcium ion (CHEBI:39124)	50: Increase, Ca++ (intracellular)
115	decreased	Follicle stimulating hormone (CHEBI:81569)	129: Reduction, Gonadotropins, circulating concentrations
33	decreased	17beta-estradiol (CHEBI:16469)	2 Events 219: Reduction, Plasma 17beta-estradiol concentrations 1056: Decrease, E2 blood concentrations at hypothalamus
6	functional change	mitochondrion (GO:0005739)	2 Events 177: Increase, Mitochondrial dysfunction 2363: Elevated mitochondrial ROS and dysfunction
114	decreased	Luteinizing hormone (CHEBI:81568)	2 Events 129: Reduction, Gonadotropins, circulating concentrations 690: Reduced, Luteinizing hormone (LH), plasma
43	morphological change	hippocampal formation (UBERON:0002421)	None
110	decreased	vitellogenins (MESH:D014819)	221: Reduction, Plasma vitellogenin concentrations
94	decreased	testosterone (CHEBI:17347)	2 Events 446: Reduction, fetal/adult testosterone 525: Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells