Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 301 to 325 of 1150 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1040 increased Celiac disease (HP:0002608) intestinal epithelial cell (CL:0002563) None
1050 pathological Celiac disease (HP:0002608) intestinal epithelial cell (CL:0002563) 2257: Celiac disease
1132 decreased cell activation (GO:0001775) fibroblast growth factor 2 (PR:000007489) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
648 decreased cell activation (GO:0001775) 1197: Activation, Fibroblasts
201 increased cell activation (GO:0001775)
1038 increased cell activation involved in immune response (GO:0002263) Peyer's patch B cell (CL:0002402) None
1039 increased cell activation involved in immune response (GO:0002263) B cell (CL:0000236) None
1068 occurrence cell activation involved in immune response (GO:0002263) None
692 increased cell activation involved in immune response (GO:0002263) leukocyte (CL:0000738) 1494: Leukocyte recruitment/activation
693 increased cell activation involved in immune response (GO:0002263) tissue-resident macrophage (CL:0000864) None
694 increased cell activation involved in immune response (GO:0002263) 1492: Tissue resident cell activation
571 increased cell death (GO:0008219) pleura (UBERON:0000977) 1086: persistent, cytotoxicity (pleura or peritoneum)
57 increased cell death (GO:0008219)
364 increased cell death (GO:0008219) kidney tubule cell (CL:1000507) 709: Increase, Cytotoxicity (renal tubular cell)
381 increased cell death (GO:0008219) bronchial epithelial cell (CL:0002328) 733: Increase, Necrosis (terminal bronchiolar cells)
384 increased cell death (GO:0008219) Clara cell (CL:0000158) 770: Increase, Cytotoxicity (club cells)
401 increased cell death (GO:0008219) corneal epithelial cell (CL:0000575) 776: Increase, Cytotoxicity (corneal cells)
407 increased cell death (GO:0008219) epithelial cell (CL:0000066) 780: Increase, Cytotoxicity (epithelial cells)
411 increased cell death (GO:0008219) nephron tubule epithelial cell (CL:1000494) 783: Increase, Cytotoxicity (tubular epithelial cells)
414 increased cell death (GO:0008219) hepatocyte (CL:0000182) 786: Increase, Cytotoxicity (hepatocytes)
420 increased cell death (GO:0008219) urothelial cell (CL:0000731) 794: Increase, Cytotoxicity (urothelial cells)
1006 increased cell death (GO:0008219) bone cell (CL:0001035) 1825: Increase, Cell death
1022 increased cell death (GO:0008219) oligodendrocyte (CL:0000128) 2265: Oligodendrocyte death, increased
1091 increased cell death (GO:0008219) cell (GO:0005623) 1825: Increase, Cell death
999 abnormal cell differentiation (GO:0030154) 2245: Altered Cell Differentiation Signaling