Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 326 to 350 of 1150 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


1106	abnormal	cell differentiation (GO:0030154)	cell (GO:0005623)	1560: Cell differentiation, altered
610	increased	cell maturation (GO:0048469)	gamete (CL:0000300)	1161: Increased, oocyte maturation
653	increased	cell motility (GO:0048870)		1241: Increased, Motility
541	increased	cell proliferation (GO:0008283)	smooth muscle cell (CL:0000192)	1042: Proliferation/Clonal Expansion, smooth muscle
552	increased	cell proliferation (GO:0008283)	acinar cell (CL:0000622)	1062: Increased, Cellular proliferation / hyperplasia of acinar cells
555	increased	cell proliferation (GO:0008283)	basal cell (CL:0000646)	1067: Proliferation/Clonal Expansion, aberrant basal-type cells
572	increased	cell proliferation (GO:0008283)	mesothelium (UBERON:0001136)	1089: Increased, Cell Proliferation (mesothelium)
1112	increased	cell proliferation (GO:0008283)	homeobox protein SIX1 (PR:000014896)	1066: Promotion, Sine oculis homeobox 1 positive progenitor cells in endometrium
1	increased	cell proliferation (GO:0008283)		3 Events 57: Proliferation, Cell proliferation in the absence of cytotoxicity 416: Increase proliferation, Leydig cell 1182: Increase, Cell Proliferation (Epithelial Cells)
204	increased	cell proliferation (GO:0008283)	memory T cell (CL:0000813)	272: Activation/Proliferation, T-cells
209	abnormal	cell proliferation (GO:0008283)	Liver cell (FMA:63179)	854: Alterations, Cellular proliferation / hyperplasia
752	decreased	cell proliferation (GO:0008283)	cell (GO:0005623)	1821: Decrease, Cell proliferation
865	increased	cell proliferation (GO:0008283)	mesothelial cell (CL:0000077)	870: Increase, Cell Proliferation
375	increased	cell proliferation (GO:0008283)	mitogenic signaling cell (CL:0000422)	716: Increase, cell proliferation (hepatocytes)
385	increased	cell proliferation (GO:0008283)	thyroid follicular cell (CL:0002258)	2 Events 739: Increase, Hypertrophy and proliferation (follicular cell) 1024: Increased, Hypertrophy and proliferation (follicular cell)
403	increased	cell proliferation (GO:0008283)	corneal epithelial cell (CL:0000575)	778: Increase, Regenerative cell proliferation (corneal cells)
408	increased	cell proliferation (GO:0008283)	epithelial cell (CL:0000066)	2 Events 781: Increase, Regenerative cell proliferation (forestomach epithelial cells) 870: Increase, Cell Proliferation
415	increased	cell proliferation (GO:0008283)	hepatocyte (CL:0000182)	787: Increase, Regenerative cell proliferation (hepatocytes)
421	increased	cell proliferation (GO:0008283)	urothelial cell (CL:0000731)	795: Increase, Regenerative cell proliferation (urothelial cells)
478	increased	cell proliferation (GO:0008283)	goblet cell (CL:0000160)	923: Increase, Proliferation of goblet cells
1069	abnormal	cell redox homeostasis (GO:0045454)		2299: Altered, Redox Homeostasis
998	increased	cell surface receptor signaling pathway (GO:0007166)		2 Events 2244: Altered Stress Response Signaling 2245: Altered Cell Differentiation Signaling
663	abnormal	cellular component organization (GO:0016043)		1258: Decompartmentalization
587	abnormal	cellular detoxification (GO:1990748)		1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
206	abnormal	cellular homeostasis (GO:0019725)		853: Changes/Inhibition, Cellular Homeostasis and Apoptosis