Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 351 to 375 of 1150 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
262 decreased ovulation (GO:0030728) 488: Decrease, Ovulation
263 decreased prostaglandin (CHEBI:26333) 685: Reduced, Prostaglandins, ovary
264 decreased reproductive process (GO:0022414) 675: Reduced, Reproductive Success
265 decreased hormone biosynthetic process (GO:0042446) testosterone (CHEBI:17347)
267 decreased sperm quantity (VT:0002673) 520: Decreased sperm quantity or quality in the adult, Decreased fertility
275 decreased receptor transactivation (GO:0035624) COUP transcription factor 2 (PR:000011405)
277 decreased sperm (CL:0000019)
280 decreased cholesterol biosynthetic process (GO:0006695) cholesterol (CHEBI:16113)
281 decreased lipoprotein transport (GO:0042953) lipoprotein (CHEBI:6495) 643: Decreased Cholesterol, Decreased Uptake of Lipoproteins
282 decreased intracellular cholesterol transport (GO:0032367) cholesterol (CHEBI:16113) 644: Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
283 decreased steroid biosynthetic process (GO:0006694) 640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
284 decreased regulation of steroid biosynthetic process (GO:0050810) 647: Decreased, steroidogenic protein expression
290 decreased dopamine beta-monooxygenase activity (GO:0004500) dopamine beta-hydroxylase (PR:000006294) 526: Inhibition, Inhibition of Dopamine-beta-hydroxylase
291 decreased norepinephrine biosynthetic process (GO:0042421) (R)-noradrenaline (CHEBI:18357) 528: Decreased, Synthesis of NE
292 decreased signaling (GO:0023052) proto-oncogene c-Fos (mouse) (PR:P01101) 529: Decreased, GnRH cfos activity
293 decreased hormone secretion (GO:0046879) Gonadotropin Releasing Hormone (MESH:D007987)
294 decreased regulation of luteinizing hormone secretion (GO:0033684) Luteinizing hormone (CHEBI:81568) 531: Decreased, LH Surge
296 decreased secretion (GO:0046903) cortical granule (GO:0060473) 533: Decreased, Cortical granule release/distribution upon fertilization
306 decreased reproductive behavior (GO:0019098) 565: Reduced, Brood care
311 decreased population of organisms (PCO:0000001) 572: Decrease, Number of worker bees
315 decreased abnormal maternal nurturing (MP:0001386) 565: Reduced, Brood care
318 decreased glucose oxidase activity (GO:0046562) D-glucono-1,5-lactone (CHEBI:16217) 578: Decreased, Glucose oxidase enzyme activity
319 decreased hydrogen peroxide biosynthetic process (GO:0050665) hydrogen peroxide (CHEBI:16240) 579: Decreased, Hydrogen peroxide production
320 decreased feeding behavior (NBO:0000079)
323 decreased receptor regulator activity (GO:0030545) 663: Desensitization, Nicotinic acetylcholine receptor