Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 376 to 400 of 1152 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


323	decreased	receptor regulator activity (GO:0030545)		663: Desensitization, Nicotinic acetylcholine receptor
325	decreased	sodium channel inhibitor activity (GO:0019871)	sodium channel protein type 1 subunit alpha (PR:000002095)	2 Events 584: Inhibition, sodium channel 598: modulation, sodium channel
326	decreased	action potential (GO:0001508)		585: Decreased, Sodium conductance 1
327	decreased	aquatic locomotion (NBO:0000371)		2 Events 586: Reduced, swimming speed 1005: Reduced, Swimming performance
328	decreased	life span trait (VT:0005372)		2 Events 592: Reduced, survival 636: Decreased, survival
330	decreased	hypoxia (MP:0005039)		590: N/A, hypoxia
331	decreased	potassium channel inhibitor activity (GO:0019870)	potassium voltage-gated channel subfamily H member 2 (human) (PR:Q12809)	593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
336	decreased	neurotransmitter reuptake (GO:0098810)	sodium-dependent serotonin transporter (PR:000015189)	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
338	decreased	serotonin secretion (GO:0001820)	sodium-dependent serotonin transporter (PR:000015189)	626: Increased, serotonin (5-HT)
339	decreased	fear/anxiety related behavior (NBO:0000018)		627: Decreased, anxiety
340	decreased	abnormal sheltering behavior (MP:0014039)		629: Decreased, sheltering
341	decreased	serotonin uptake (GO:0051610)	sodium-dependent serotonin transporter (PR:000015189)	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
342	decreased	histamine receptor activity (GO:0004969)	histamine H2 receptor (PR:000001423)	638: Antagonism, Histamine Receptor (H2)
343	decreased	rhythmic excitation (GO:0043179)	histaminergic neuron (CL:0011110)	633: Decrease, histaminergic neuron excitation
344	decreased	locomotion (GO:0040011)		635: Decreased, locomotion
346	decreased		prostaglandin F2alpha (CHEBI:15553)	2 Events 671: Reduced, Prostaglandin F2alpha concentration, plasma 1104: Decreased, Prostaglandin F2alpha concentration, plasma
347	decreased	prostaglandin biosynthetic process (GO:0001516)	prostaglandin F2alpha (CHEBI:15553)	2 Events 672: Reduced, Prostaglandin F2alpha synthesis, ovary 681: Decreased, Prostaglandin F2alpha synthesis, ovary
349	decreased	attraction-related behavior (NBO:0000280)		674: Reduced, Ability to attract spawning mates
350	decreased	reproduction (GO:0000003)		2 Events 675: Reduced, Reproductive Success 1277: Reproductive failure
351	decreased	mating pheromone secretion (GO:0071834)	pheromone (CHEBI:26013)	678: Reduced, Pheromone release
353	decreased		Gonadotropin Releasing Hormone (MESH:D007987)	689: Reduced, Gonadotropin releasing hormone, hypothalamus
354	decreased		steroid hormone (CHEBI:26764)	691: Reduced, Maturation inducing steroid, plasma
355	decreased	steroid hormone receptor activity (GO:0003707)	steroid hormone (CHEBI:26764)	692: Reduced, Maturation inducing steroid receptor signalling, oocyte
356	decreased	G2/MI transition of meiotic cell cycle (GO:0008315)		694: Reduced, Meiotic prophase I/metaphase I transition, oocyte
358	decreased	signaling (GO:0023052)	steroid hormone (CHEBI:26764)	692: Reduced, Maturation inducing steroid receptor signalling, oocyte