Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 376 to 400 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1053 occurrence gene conversion of immunoglobulin genes (GO:0002206) B cell receptor complex (GO:0019815) 2254: Gluten-reactive and transglutaminase 2 reactive B cell receptors, generation
1054 occurrence T cell migration (GO:0072678) T cell (CL:0000084) 2275: Gluten reactive adaptive T-cells with antigen presenting cells, co-localization
1055 occurrence dendritic cell migration (GO:0036336) professional antigen presenting cell (CL:0000145) 2275: Gluten reactive adaptive T-cells with antigen presenting cells, co-localization
1056 occurrence immune system process (GO:0002376) 2255: Innate immune response, activation
1057 occurrence T cell activation involved in immune response (GO:0002286) T cell (CL:0000084) 2260: Gluten-reactive CD4+ T cells, activation
1058 occurrence B cell activation involved in immune response (GO:0002312) B cell (CL:0000236) 2256: Gluten-reactive B cells and transglutaminase 2-reactive B cells, activation
1059 decreased retinoic acid biosynthetic process (GO:0002138) retinal dehydrogenase 1 (PR:000003920) 1880: Decreased, ALDH1A (RALDH) enzyme activity
1060 decreased retinoic acid biosynthetic process (GO:0002138) all-trans-retinoic acid (CHEBI:15367) 1881: Decreased, all-trans retinoic acid (atRA) concentration
1061 decreased ovarian follicle development (GO:0001541) ovarian follicle (UBERON:0001305) 1883: Decreased, size of the ovarian reserve
1062 disrupted meiosis I (GO:0007127) oocyte (CL:0000023) 1882: Disrupted, initiation of meiosis of oogonia in the ovary
1063 disrupted ovulation cycle (GO:0042698) ovarian follicle (UBERON:0001305) 405: disrupted, ovarian cycle
1064 decreased fertilization (GO:0009566) fertility (MESH:D005298) 406: decreased, Fertility
1065 decreased ovulation (GO:0030728) Ovum (FMA:67343) 1695: Impaired ovulation
1069 abnormal cell redox homeostasis (GO:0045454) 2299: Altered, Redox Homeostasis
1070 disrupted glucose metabolic process (GO:0006006) 2300: Disruption, Glucolipid metabolism
1071 disrupted abnormal lipid metabolism (MP:0013245) 2300: Disruption, Glucolipid metabolism
1072 abnormal behavior (GO:0007610) 2301: Abnormal, Behavior
1073 increased aryl hydrocarbon receptor binding (GO:0017162) aryl hydrocarbon receptor (PR:000003858) 18: Activation, AhR
1074 occurrence cornification (GO:0070268) epithelium of vagina (UBERON:0001344) 2306: Persistent vaginal cornification
1075 increased serotonin receptor activity (GO:0099589) Surface of brain (FMA:86594) 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
1076 increased increased serotonin level (MP:0010069) extracellular region (GO:0005576) 1320: Increased, extracellular serotonin
1077 increased increased serotonin level (MP:0010069) serotonin (CHEBI:28790) 1320: Increased, extracellular serotonin
1079 abnormal embryonic organ development (GO:0048568) penis (UBERON:0000989) 2082: Hypospadias, increased
1080 increased serotonin receptor signaling pathway (GO:0007210) 5-hydroxytryptamine receptor 1A (PR:000001161) 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
1128 decreased mesenchymal-epithelial cell signaling (GO:0060638) fibroblast growth factor receptor 2 (PR:000001449) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced