Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 401 to 425 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
362 decreased ion channel activity (GO:0005216) potassium voltage-gated channel subfamily H member 2 (human) (PR:Q12809) 697: impaired, ion channels
363 decreased ion channel activity (GO:0005216) ATP-sensitive inward rectifier potassium channel 1 (PR:000001978) 697: impaired, ion channels
374 decreased spindle organization (GO:0007051) spindle (GO:0005819) 721: Disorganization, Meiotic Spindle
380 decreased pyruvate dehydrogenase activity (GO:0004738) Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (rat) (PR:Q63065) 724: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
389 decreased receptor binding (GO:0005102) testosterone (CHEBI:17347) 743: Decreased, Testosterone binding to androgen receptor (hypothalamus)
393 decreased Prolactin (CHEBI:81580) 747: Decreased, Prolactin
394 decreased progesterone secretion (GO:0042701) progesterone (CHEBI:17026) 749: Decreased, Progesterone from corpus luteum
398 decreased population quality (PCO:0000003) 765: Decreased, population 1
406 decreased 4-hydroxyphenylpyruvate dioxygenase activity (GO:0003868) 4-hydroxyphenylpyruvate dioxygenase (rat) (PR:P32755) 766: Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme
416 decreased catalytic activity (GO:0003824) iodotyrosine deiodinase 1 (mouse) (PR:Q9DCX8) 788: Decrease, Incorporation of active iodide into iodotyrosines
418 decreased catalytic activity (GO:0003824) 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (rat) (PR:P31214) None
423 decreased aromatase activity (GO:0070330) aromatase isoform 1 (PR:000038849) 800: Decreased, Aromatase (Cyp19a1) mRNA
425 decreased catalytic activity (GO:0003824) Prolyl hydroxylases (MESH:D064828) 798: Inhibition, Prolyl hydroxylases
428 decreased mevalonate (CHEBI:25350) 805: Decreased, mevalonate
429 decreased cholesterol (CHEBI:16113) None
430 decreased hydroxymethylglutaryl-CoA reductase activity (GO:0042282) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (PR:000008636) 804: Inhibition, HMG-CoA reductase
432 decreased reduced fertility (MP:0001921) fertility (MESH:D005298) 527: Decreased, Decreased fecundity
433 decreased hormone secretion (GO:0046879) Luteinizing hormone (CHEBI:81568)
434 decreased norepinephrine binding (GO:0051380) (R)-noradrenaline (CHEBI:18357) 848: Decreased, Binding of NE to NE receptors on GnRH neurons
435 decreased signaling (GO:0023052) alpha-2A adrenergic receptor (PR:000001186) 849: Inhibition, Antgonism of NE receptor
436 decreased glomerular filtration (GO:0003094) 819: Decreased, Glomerular filtration
437 decreased kidney plasma flow trait (VT:0005524) 820: Decreased, Renal plasma flow
438 decreased renal absorption (GO:0070293) sodium(1+) (CHEBI:29101) 821: Decreased, Sodium reabsorption
439 decreased function (MI:0613) kidney (UBERON:0002113) 825: Decreased, Renal ability to dilute urine
449 decreased phospholipase activity (GO:0004620) phospholipase A1 member A (human) (PR:Q53H76) 828: Inhibition, Phospholipase A