Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 401 to 425 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1117 decreased Decreased circulating gonadotropin level (HP:0030339) circulatory system (UBERON:0001009) 1986: Decreased, Gonadotropins
1118 increased prolonged estrous cycle (MP:0009006) 1075: prolonged, estrus cycle
1119 increased prolonged estrus (MP:0009017) 1075: prolonged, estrus cycle
1120 decreased neurotransmitter secretion (GO:0007269) Metastin (CHEBI:80304) 968: Decreased, release of kisspeptin from anteroventral periventricular nucleus (AVPV) neurons
1121 increased hormone secretion (GO:0046879) gonadotropin releasing neuron (CL:0011111) 2137: Increase, Gonadotropins concentration in plasma
1122 increased hormone secretion (GO:0046879) Gonadotropin Releasing Hormone (MESH:D007987) 1047: Increased, secretion of GnRH from hypothalamus
1124 increased regulation of vascular permeability (GO:0043114) 2384: Decrease, Vascular integrity
1126 decreased protein import into nucleus, translocation (GO:0000060) androgen receptor (PR:000004191) 2393: Androgen receptor nuclear transcriptional activity in genital-tubercle tissues, reduced
1127 decreased regulation of DNA binding (GO:0051101) androgen (CHEBI:50113) 2393: Androgen receptor nuclear transcriptional activity in genital-tubercle tissues, reduced
1128 decreased mesenchymal-epithelial cell signaling (GO:0060638) fibroblast growth factor receptor 2 (PR:000001449) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1129 decreased mesenchymal-epithelial cell signaling (GO:0060638) fibroblast growth factor 10 (PR:000007480) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1130 decreased fibroblast growth factor 10 (PR:000007480) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1132 decreased cell activation (GO:0001775) fibroblast growth factor 2 (PR:000007489) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1133 disrupted external genitalia morphogenesis (GO:0035261) prepuce (UBERON:0011374) 2400: Preputial epithelial morphogenesis, disrupted
1134 delayed delayed balanopreputial separation (MP:0008940) prepuce of penis (UBERON:0001332) 2401: Male preputial separation, failed/delayed
1145 increased female gonad development (GO:0008585) immature gonad (UBERON:2005272) 2417: Increased, differentiation to ovaries
1152 disrupted Abnormality of cellular immune system (HP:0010987) activated CD8-positive, alpha-beta T cell (CL:0000906) 2326: CTL cytotoxic activity disruption
1151 abnormal Abnormality of cellular immune system (HP:0010987) alpha-beta T cell (CL:0000789) 2324: Increased of Treg/Th17 cell ratio
1150 increased Abnormality of cellular immune system (HP:0010987) B7-related protein (PR:000001290) 2323: Over-expression of PD-L1 in cancer cells
1149 increased androgen receptor signaling pathway (GO:0030521) Musculature of female perineum (FMA:264623) 2365: Anogenital distance (AGD), increased
1148 occurrence Amyotrophic lateral sclerosis (HP:0007354) adult central nervous system (UBERON:6003623) 2416: human amyotrophic lateral sclerosis (ALS)
1147 increased protein oxidation (GO:0018158) 1767: Increase, Protein oxidation
1146 increased Hepatic bridging fibrosis (HP:0012852) 2414: COL3A1 Signaling Pathway
1138 increased neurotransmitter secretion (GO:0007269) Metastin (CHEBI:80304) 1985: Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV)
1139 increased increased circulating estradiol level (MP:0005182) 17beta-estradiol (CHEBI:16469) 2294: Plasma estradiol, increased