Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 401 to 425 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
286 abnormal cytoskeleton organization (GO:0007010) Leydig cell (CL:0000178) 649: Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton
359 increased deactivation of mitotic spindle assembly checkpoint (GO:1902426) MAD2 like protein (fruit fly) (PR:Q9VNE1) 695: Upregulated, Spindle assembly checkpoint protein Mad2-oocyte
1115 decreased Decreased activity of mitochondrial complex III (HP:0011924) mitochondrial respiratory chain complex III (GO:0005750) 1542: Inhibition, Mitochondrial complex III
940 decreased decreased body weight (MP:0001262) 864: Decreased, Body Weight
1008 occurrence decreased bone mineral density (MP:0000063) 2091: Occurrence, Bone Loss
1117 decreased Decreased circulating gonadotropin level (HP:0030339) circulatory system (UBERON:0001009) 1986: Decreased, Gonadotropins
1017 decreased decreased circulating sodium level (MP:0005634) blood plasma (UBERON:0001969) 2237: Decreased, Plasma sodium concentrations
1024 decreased decreased circulating total protein level (MP:0005567) None
1047 decreased decreased circulating total protein level (MP:0005567) insulin-induced gene 1 protein (PR:000009056) 2268: Decreased, insulin-induced gene 1 (INSIG1) protein activity
159 decreased Decreased liver function (HP:0001410) 164: Induction, Liver “Dysfunctional” Changes by CGA 330050
1088 decreased decreased neurotransmitter release (MP:0003990) CNS neuron (sensu Vertebrata) (CL:0000117) 1944: Synaptic dysfunction
1007 occurrence decreased trabecular bone volume (MP:0010879) 2091: Occurrence, Bone Loss
898 decreased decreased triiodothyronine level (MP:0005473) 3,3',5'-triiodothyronine (CHEBI:28774) 1003: Decreased, Triiodothyronine (T3)
1134 delayed delayed balanopreputial separation (MP:0008940) prepuce of penis (UBERON:0001332) 2401: Male preputial separation, failed/delayed
1135 arrested delayed balanopreputial separation (MP:0008940) prepuce of penis (UBERON:0001332) 2401: Male preputial separation, failed/delayed
1097 decreased Dementia (HP:0000726) drebrin (PR:000006296) 2242: Abnormality, dendritic spine morphology
996 increased demyelination (MP:0000921)
60 abnormal dendrite morphogenesis (GO:0048813) dendrite (GO:0030425) 382: Aberrant, Dendritic morphology
1043 increased dendritic cell migration (GO:0036336) professional antigen presenting cell (CL:0000145) None
1055 occurrence dendritic cell migration (GO:0036336) professional antigen presenting cell (CL:0000145) 2275: Gluten reactive adaptive T-cells with antigen presenting cells, co-localization
1101 decreased dendritic spine morphogenesis (GO:0060997) actin cytoskeleton (GO:0015629) 2078: Loss of drebrin
622 increased dermatitis (MP:0001194)
98 arrested developmental process (GO:0032502) male reproductive organ (UBERON:0003135) 240: Feminisation or incomplete development, Primary and accessory male sex organs
104 morphological change developmental process (GO:0032502) cardiovascular system (UBERON:0004535) None
143 abnormal developmental process (GO:0032502) reproductive organ (UBERON:0003133) 364: Impaired development of, Reproductive organs