Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 426 to 450 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1121 increased hormone secretion (GO:0046879) gonadotropin releasing neuron (CL:0011111) 2137: Increase, Gonadotropins concentration in plasma
1120 decreased neurotransmitter secretion (GO:0007269) Metastin (CHEBI:80304) 968: Decreased, release of kisspeptin from anteroventral periventricular nucleus (AVPV) neurons
1119 increased prolonged estrus (MP:0009017) 1075: prolonged, estrus cycle
1118 increased prolonged estrous cycle (MP:0009006) 1075: prolonged, estrus cycle
1117 decreased Decreased circulating gonadotropin level (HP:0030339) circulatory system (UBERON:0001009) 1986: Decreased, Gonadotropins
1098 decreased long term synaptic depression (GO:0060292) drebrin (PR:000006296) 2242: Abnormality, dendritic spine morphology
1082 increased estradiol secretion (GO:0035938) Glandular part of endometrium (FMA:86488) 2251: Estradiol availability, increased
1083 increased aromatase activity (GO:0070330) aromatase (PR:000006100) 2293: Aromatase, induction
1084 increased apoptosis regulator BAX (PR:000002193) 2124: increased, Bax expression
1085 increased wounding (MP:0013027) Nose (FMA:46472) 2312: Increased, nasal lesions
1086 decreased cytochrome-c oxidase activity (GO:0004129) mitochondrion (GO:0005739) 1840: Inhibition, cytochrome oxidase
1087 decreased Premature ovarian failure (HP:0008209) ovarian follicle (UBERON:0001305) 2305: Premature ovarian Insufficiency
1088 decreased decreased neurotransmitter release (MP:0003990) CNS neuron (sensu Vertebrata) (CL:0000117) 1944: Synaptic dysfunction
1089 increased Pulmonary edema (HP:0100598) lung (UBERON:0002048) 2316: Increased, pulmonary edema
1090 decreased response to odorant (GO:1990834) Nose (FMA:46472) 2317: Loss of olfactory function
1091 increased cell death (GO:0008219) cell (GO:0005623) 1825: Increase, Cell death
1094 decreased ovarian follicle development (GO:0001541) granulosa cell (CL:0000501) 1800: Granulosa cell proliferation of gonadotropin-independent follicles, Reduced
1095 increased palatal shelves fail to meet at midline (MP:0009888) primary palate (UBERON:0005620) 2041: Decrease, facial prominence outgrowth
1096 increased palatal shelves fail to meet at midline (MP:0009888) secondary palate (UBERON:0001716) 2041: Decrease, facial prominence outgrowth
1097 decreased Dementia (HP:0000726) drebrin (PR:000006296) 2242: Abnormality, dendritic spine morphology
1112 increased cell proliferation (GO:0008283) homeobox protein SIX1 (PR:000014896) 1066: Promotion, Sine oculis homeobox 1 positive progenitor cells in endometrium
1109 increased Metaplasia (MESH:D008679) endometrium epithelium (UBERON:0004811) 1068: Endometrial squamous metaplasia, Increase
1110 decreased cellular response to oxidative stress (GO:0034599) 1869: Diminished protective oxidative stress response
1111 increased translation (GO:0006412) homeobox protein SIX1 (PR:000014896) 2330: Sine oculis homeobox 1 protein expression, increased
1114 increased peptide biosynthetic process (GO:0043043) 2371: Increased cortisol