Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 426 to 450 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
317 abnormal developmental process (GO:0032502) 577: impaired, Development
444 occurrence Dilatation (MESH:D004106) renal tubule (UBERON:0009773) 823: Occurrence, Cystic dilatation (renal tubule)
71 increased Disease Susceptibility (MESH:D004198) 323: Increased, Disease susceptibility
72 increased DNA alkylation (GO:0006305) deoxyribonucleic acid (CHEBI:16991) 97: Alkylation, DNA
224 abnormal DNA alkylation (GO:0006305) Nuclear deoxyribonucleic acid (FMA:67194) 373: Formation, Pro-mutagenic DNA Adducts
860 increased DNA damage response, detection of DNA damage (GO:0042769) site of DNA damage (GO:0090734)
300 increased DNA hypermethylation (GO:0044026) 662: Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis
310 abnormal DNA repair (GO:0006281) Mitochondrial deoxyribonucleic acid (FMA:67199) 664: Overwhelmed, Mitochondrial DNA repair mechanisms
1000 abnormal DNA repair (GO:0006281) deoxyribonucleic acid (CHEBI:16991) 155: Inadequate DNA repair
670 increased DNA repair (GO:0006281) deoxyribonucleic acid (CHEBI:16991) 1281: Increased, DNA Damage-Repair
74 functional change DNA repair (GO:0006281) deoxyribonucleic acid (CHEBI:16991) None
228 functional change DNA repair (GO:0006281) Nuclear deoxyribonucleic acid (FMA:67194) 493: Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts
994 increased DNA Strand Break (NCI:C25830) Deoxyribonucleic acid (FMA:74412) 1635: Increase, DNA strand breaks
661 abnormal DNA topoisomerase II activity (GO:0061505) 1252: Binding to (interferes with) topoisomerase II enzyme
290 decreased dopamine beta-monooxygenase activity (GO:0004500) dopamine beta-hydroxylase (PR:000006294) 526: Inhibition, Inhibition of Dopamine-beta-hydroxylase
13 decreased ecdysis-triggering hormone activity (GO:0008255) 988: Decrease, Circulating ecdysis triggering hormone
750 decreased ecdysis, chitin-based cuticle (GO:0018990) 1524: Increase, Premature molting
12 increased ecdysone receptor-mediated signaling pathway (GO:0035076) ecdysone receptor holocomplex (GO:0008230) 103: Increase, Ecdysone receptor hyperactivation
736 occurrence EEG with focal epileptiform discharges (HP:0011185) neuron part (GO:0097458) None
737 occurrence EEG with focal epileptiform discharges (HP:0011185) neuron (CL:0000540) 1623: Occurrence, Focal Seizure
109 decreased egg quantity (VT:1000294)
837 increased Elevated C-reactive protein level (HP:0011227) C-reactive protein (PR:000005897) 1868: Hyperinflammation
684 abnormal embryo development (GO:0009790) 1295: Defect of Embryogenesis
497 increased embryonic lethality (MP:0008762) 947: Increase, Early Life Stage Mortality
1079 abnormal embryonic organ development (GO:0048568) penis (UBERON:0000989) 2082: Hypospadias, increased