Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 451 to 475 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
118 disrupted mitochondrial respiratory chain (GO:0005746) 178: Mitochondrial electron transport chain, disrupted
559 disrupted abnormal ovulation (MP:0001928) 1074: interruption, Ovulation
701 disrupted regulation of cell cycle (GO:0051726) cell cycle-related cyclin (PR:000029191) 1505: Increase, Cell cycle disruption
722 disrupted tubulin complex (GO:0045298) 718: Binding, Tubulin
732 disrupted androgen receptor signaling pathway (GO:0030521) Musculature of male perineum (FMA:264621) 1688: anogenital distance (AGD), decreased
770 disrupted mRNA transcription (GO:0009299) angiotensin-converting enzyme 2 (PR:000003622) None
839 disrupted barrier epithelial cell (CL:0000073) 1931: Intestinal barrier, disruption
851 disrupted action potential (GO:0001508) 1983: Disruption, action potential generation
927 disrupted intercellular transport (GO:0010496) 2096: Occurrence, (Micro)vascular dysfunction
975 disrupted peroxisome proliferator activated receptor signaling pathway (GO:0035357) 2227: Disrupted PPAR isoform nuclear signaling
976 disrupted regulation of gene expression (GO:0010468) 2224: Dysregulation of transcriptional expression within PPAR signaling network
977 disrupted lipid storage (GO:0019915) 2225: Disrupted Lipid Storage
984 disrupted synapse (GO:0045202) 2005: Altered neurotransmission in development
985 disrupted voltage-gated sodium channel activity (GO:0005248) 1353: Binding to voltage-gated sodium channel
1062 disrupted meiosis I (GO:0007127) oocyte (CL:0000023) 1882: Disrupted, initiation of meiosis of oogonia in the ovary
1063 disrupted ovulation cycle (GO:0042698) ovarian follicle (UBERON:0001305) 405: disrupted, ovarian cycle
1070 disrupted glucose metabolic process (GO:0006006) 2300: Disruption, Glucolipid metabolism
1071 disrupted abnormal lipid metabolism (MP:0013245) 2300: Disruption, Glucolipid metabolism
1133 disrupted external genitalia morphogenesis (GO:0035261) prepuce (UBERON:0011374) 2400: Preputial epithelial morphogenesis, disrupted
1152 disrupted Abnormality of cellular immune system (HP:0010987) activated CD8-positive, alpha-beta T cell (CL:0000906) 2326: CTL cytotoxic activity disruption
6 functional change mitochondrion (GO:0005739)
74 functional change DNA repair (GO:0006281) deoxyribonucleic acid (CHEBI:16991) None
135 functional change eggshell (UBERON:0005079) 119: N/A, Gap
177 functional change mitochondrion disassembly (GO:0061726) mitochondrion (GO:0005739) None
228 functional change DNA repair (GO:0006281) Nuclear deoxyribonucleic acid (FMA:67194) 493: Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts