Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 51 to 75 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
693 increased cell activation involved in immune response (GO:0002263) tissue-resident macrophage (CL:0000864) None
809 decreased cftr isoform 1 (PR:000001045) None
755 increased viral RNA genome replication (GO:0039694) None
718 decreased hypoxia-inducible factor-1alpha signaling pathway (GO:0097411) von Hippel-Lindau disease tumor suppressor (PR:000017294) None
365 increased epithelial cell proliferation (GO:0050673) nephron tubule epithelial cell (CL:1000494) None
769 increased neuropilin binding (GO:0038191) None
482 occurrence mucus secretion (GO:0070254) None
814 decreased angiotensin-converting enzyme 2 (PR:000003622) None
792 decreased epithelial cilium movement (GO:0003351) None
36 disrupted ovulation cycle (GO:0042698) None
556 morphological change Metaplasia (MESH:D008679) None
103 disrupted protein dimerization activity (GO:0046983) aryl hydrocarbon receptor nuclear translocator (PR:000004303) None
104 morphological change developmental process (GO:0032502) cardiovascular system (UBERON:0004535) None
573 increased mesothelioma (MESH:D008654) None
31 decreased weight loss (MP:0001263) None
827 increased Increased inflammatory response (HP:0012649) interleukin-6 (PR:000001393) None
812 increased mRNA transcription (GO:0009299) angiotensin-converting enzyme 2 (human) (PR:Q9BYF1) None
719 increased hypoxia-inducible factor-1alpha signaling pathway (GO:0097411) None
760 increased viral RNA genome packaging (GO:0019074) None
767 increased endocytosis involved in viral entry into host cell (GO:0075509) None
793 decreased regulation of cilium movement (GO:0003352) None
770 disrupted mRNA transcription (GO:0009299) angiotensin-converting enzyme 2 (PR:000003622) None
713 decreased abnormal circulating hormone level (MP:0005418) None
729 decreased activin receptor signaling pathway (GO:0032924) activin complex (GO:0048180) None
743 decreased regulation of binding (GO:0051098) None