Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 851 to 875 of 1150 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
322 increased acetylcholine receptor activator activity (GO:0030549) Nicotinic acetylcholine receptor (FMA:61796) 663: Desensitization, Nicotinic acetylcholine receptor
487 decreased nitric oxide biosynthetic process (GO:0006809) nitric oxide (CHEBI:16480) 933: KE6 : Depletion, Nitric Oxide
121 decreased nitric oxide (CHEBI:16480) 193: Decreased, Nitric Oxide
160 decreased nitric-oxide synthase activity (GO:0004517) nitric oxide synthase, brain (PR:000011326) 147: Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307
485 decreased catalytic activity (GO:0003824) nitric oxide synthase, endothelial (PR:000011328) 973: KE5 : Decrease, AKT/eNOS activity
492 increased protein glutathionylation (GO:0010731) nitric oxide synthase, endothelial (PR:000011328) 927: KE1 : S-Glutathionylation, eNOS
494 functional change nitric oxide synthase, endothelial (PR:000011328) 932: KE4 : Uncoupling, eNOS
806 increased NLRP3 inflammasome complex assembly (GO:0044546) NLRP3 inflammasome complex (GO:0072559) 1895: NLRP3 inflammasome activity, increased
685 decreased NMDA glutamate receptor activity (GO:0004972) NMDA selective glutamate receptor complex (GO:0017146) 195: Inhibition, NMDARs
686 increased NMDA glutamate receptor activity (GO:0004972) NMDA selective glutamate receptor complex (GO:0017146) 388: Overactivation, NMDARs
1085 increased wounding (MP:0013027) Nose (FMA:46472) 2312: Increased, nasal lesions
1090 decreased response to odorant (GO:1990834) Nose (FMA:46472) 2317: Loss of olfactory function
224 abnormal DNA alkylation (GO:0006305) Nuclear deoxyribonucleic acid (FMA:67194) 373: Formation, Pro-mutagenic DNA Adducts
228 functional change DNA repair (GO:0006281) Nuclear deoxyribonucleic acid (FMA:67194) 493: Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts
254 increased signaling (GO:0023052) nuclear factor erythroid 2-related factor 2 (PR:000011170) 478: Activation, NRF2
18 increased gene expression (GO:0010467) nuclear hormone receptor FTZ-F1 (fruit fly) (PR:P33244) 1265: Decrease, Fushi tarazu factor-1 gene expression
24 increased transcription corepressor activity (GO:0003714) nuclear receptor corepressor 1 (PR:000011047) 1000: stabilization, PPAR alpha co-repressor
23 increased transcription corepressor activity (GO:0003714) nuclear receptor corepressor 2 (PR:000011048) 1000: stabilization, PPAR alpha co-repressor
256 increased signaling (GO:0023052) nuclear receptor subfamily 0 group B member 2 (PR:000011391) 480: Activation, SHP
37 increased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 2 (PR:000011397)
38 increased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 3 (PR:000011398) 715: Activation, Constitutive androstane receptor
244 decreased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 3 (PR:000011398) 456: Suppression, Constitutive androstane receptor, NR1I3
586 decreased transport (GO:0006810) nutrient (CHEBI:33284) 1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
460 increased atrophy (MESH:D001284) olfactory epithelium (UBERON:0001997) 868: Increase, Tissue Degeneration, Necrosis & Atrophy
463 increased neoplasm (MP:0002006) olfactory segment of nasal mucosa (UBERON:0005386) 872: Increase, Site of Contact Nasal Tumors