Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 901 to 925 of 1150 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
968 abnormal animal organ formation (GO:0048645) urethra (UBERON:0000057) 2213: Impaired, urethral tube closure
970 increased increased apoptosis (MP:0006042) 1513: General Apoptosis
973 abnormal animal organ development (GO:0048513) 1616: Malformation, cryptorchidism - maldescended testis
974 occurrence epithelial to mesenchymal transition (GO:0001837) Epithelial cell (FMA:66768) 1457: Epithelial Mesenchymal Transition
975 disrupted peroxisome proliferator activated receptor signaling pathway (GO:0035357) 2227: Disrupted PPAR isoform nuclear signaling
976 disrupted regulation of gene expression (GO:0010468) 2224: Dysregulation of transcriptional expression within PPAR signaling network
977 disrupted lipid storage (GO:0019915) 2225: Disrupted Lipid Storage
978 decreased interleukin-1 receptor activity (GO:0004908) interleukin-1 receptor type I (PR:000001363) 1700: Impaired IL-1R1 signaling in T cell
979 abnormal animal organ development (GO:0048513) gonad (UBERON:0000991) 1615: Impaired inguinoscrotal testicular descent phase
980 pathological negative regulation of synaptic plasticity (GO:0031914) postsynaptic actin cytoskeleton (GO:0098871) 2242: Abnormality, dendritic spine morphology
981 morphological change abnormal excitatory postsynaptic current amplitude (MP:0011267) dendritic spine membrane (GO:0032591) 388: Overactivation, NMDARs
983 decreased postsynaptic actin cytoskeleton organization (GO:0098974) drebrin (PR:000006296) 2078: Loss of drebrin
984 disrupted synapse (GO:0045202) 2005: Altered neurotransmission in development
985 disrupted voltage-gated sodium channel activity (GO:0005248) 1353: Binding to voltage-gated sodium channel
986 functional change sodium channel activity (GO:0005272) voltage-gated sodium channel complex (GO:0001518) 1977: Disruption of sodium channel gating kinetics
989 increased blood viscosity trait (VT:3000004) blood (UBERON:0000178) 2238: Increased, Blood viscosity
991 occurrence Cardiac arrest (HP:0001695) heart (UBERON:0000948) 1535: Heart failure
992 increased estradiol (CHEBI:23965) 2251: Estradiol availability, increased
993 increased energy deposition event (RBO:00015021) 1686: Deposition of Energy
994 increased DNA Strand Break (NCI:C25830) Deoxyribonucleic acid (FMA:74412) 1635: Increase, DNA strand breaks
995 decreased neurogenesis (GO:0022008) 2098: Increase, Abnormal Neural Remodeling
997 increased neuron death (GO:0070997) 2098: Increase, Abnormal Neural Remodeling
999 abnormal cell differentiation (GO:0030154) 2245: Altered Cell Differentiation Signaling
1000 abnormal DNA repair (GO:0006281) deoxyribonucleic acid (CHEBI:16991) 155: Inadequate DNA repair
1001 decreased bone mineralization (GO:0030282) 2090: Increase, Bone Remodeling