Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 926 to 950 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
562 increased prolactin (PR:000013246) 1077: Increased, prolactin exposure
569 increased prolactin secretion (GO:0070459) prolactin (PR:000013246) 1084: Increased, prolactin secretion
565 increased hyperplasia (MESH:D006965) prolactin secreting cell (CL:0000439) 1081: Increased, lactotroph hyperplasia and hypertrophy
566 increased hypertrophy (MESH:D006984) prolactin secreting cell (CL:0000439) 1081: Increased, lactotroph hyperplasia and hypertrophy
425 decreased catalytic activity (GO:0003824) Prolyl hydroxylases (MESH:D064828) 798: Inhibition, Prolyl hydroxylases
1049 increased increased circulating total protein level (MP:0005568) proprotein convertase subtilisin/kexin type 9 (PR:000012440) 2276: Increased, protein expression of proprotein convertase subtilisin/kexin type 9 (PCSK9)
263 decreased prostaglandin (CHEBI:26333) 685: Reduced, Prostaglandins, ovary
132 decreased prostaglandin E2 (CHEBI:15551)
346 decreased prostaglandin F2alpha (CHEBI:15553)
347 decreased prostaglandin biosynthetic process (GO:0001516) prostaglandin F2alpha (CHEBI:15553)
130 decreased prostaglandin-endoperoxide synthase activity (GO:0004666) prostaglandin G/H synthase 1 (PR:000013427)
106 increased gene expression (GO:0010467) prostaglandin G/H synthase 2 (PR:000013428) 1269: Increase, COX-2 expression
131 decreased prostaglandin-endoperoxide synthase activity (GO:0004666) prostaglandin G/H synthase 2 (PR:000013428) 79: Inhibition, Cyclooxygenase activity
7 abnormal Proteostasis deficiencies (MESH:D057165) protein (CHEBI:36080) 889: Proteostasis, impaired
607 increased signaling (GO:0023052) protein (PR:000000001) 1157: Activation, Hepatic nuclear receptor(s)
633 increased oxidation-reduction process (GO:0055114) protein (PR:000000001) 1238: Activation of oxidative stress pathway
652 abnormal translation (GO:0006412) protein (PR:000000001) 1240: Altered, Protein Production
656 increased gene expression (GO:0010467) protein doublesex (fruit fly) (PR:P23023) 1206: Induction, Doublesex1 gene
745 decreased negative regulation of DNA binding (GO:0043392) protein-DNA complex (GO:0032993) 1717: Suppression of STAT5 binding to cytokine gene promoters
725 increased Wnt protein secretion (GO:0061355) protein-serine O-palmitoleoyltransferase porcupine (PR:000030936) 1754: Increase, porcupine-induced Wnt secretion and Wnt signaling activation
582 decreased carboxylation reaction (MI:1139) prothrombin (PR:000007299) 1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)
292 decreased signaling (GO:0023052) proto-oncogene c-Fos (mouse) (PR:P01101) 529: Decreased, GnRH cfos activity
380 decreased pyruvate dehydrogenase activity (GO:0004738) Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (rat) (PR:Q63065) 724: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
379 increased pyruvate dehydrogenase activity (GO:0004738) pyruvate dehydrogenase [ubiquinone] (PR:000023575) 726: Increased, Induction of pyruvate dehydrogenase (PDH)
261 increased signaling (GO:0023052) RAC-beta serine/threonine-protein kinase (PR:000003912) 484: Activation, AKT2