Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 76 to 100 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
97 abnormal Wnt signaling pathway (GO:0016055) Wnt signalosome (GO:1990909) 310: Alteration, Wnt pathway
98 arrested developmental process (GO:0032502) male reproductive organ (UBERON:0003135) 240: Feminisation or incomplete development, Primary and accessory male sex organs
1135 arrested delayed balanopreputial separation (MP:0008940) prepuce of penis (UBERON:0001332) 2401: Male preputial separation, failed/delayed
1092 arrested androgen receptor signaling pathway (GO:0030521) androgen receptor (PR:000004191) None
265 decreased hormone biosynthetic process (GO:0042446) testosterone (CHEBI:17347)
249 decreased signaling (GO:0023052) hepatocyte nuclear factor 4-alpha (PR:000008654) 461: Suppression, HNF4alpha
235 decreased sodium:iodide symporter activity (GO:0008507) sodium/iodide cotransporter (PR:000015171) 424: Inhibition, Na+/I- symporter (NIS)
283 decreased steroid biosynthetic process (GO:0006694) 640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
277 decreased sperm (CL:0000019)
252 decreased gene expression (GO:0010467) hydroxymethylglutaryl-CoA synthase, mitochondrial (PR:000008638) 474: Down Regulation, HMGCS2
267 decreased sperm quantity (VT:0002673) 520: Decreased sperm quantity or quality in the adult, Decreased fertility
284 decreased regulation of steroid biosynthetic process (GO:0050810) 647: Decreased, steroidogenic protein expression
264 decreased reproductive process (GO:0022414) 675: Reduced, Reproductive Success
238 decreased secretion (GO:0046903) very-low-density lipoprotein (CHEBI:39027) 450: Decrease, Very low-density lipoprotein export capacity
236 decreased iodide transport (GO:0015705) iodide (CHEBI:16382)
244 decreased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 3 (PR:000011398) 456: Suppression, Constitutive androstane receptor, NR1I3
257 decreased catalytic activity (GO:0003824) 17-beta-hydroxysteroid dehydrogenase 14 (PR:000008778) 482: Decreased, DHB4/HSD17B4
239 decreased gene expression (GO:0010467) phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PR:000012416) 216: Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway)
280 decreased cholesterol biosynthetic process (GO:0006695) cholesterol (CHEBI:16113)
275 decreased receptor transactivation (GO:0035624) COUP transcription factor 2 (PR:000011405)
263 decreased prostaglandin (CHEBI:26333) 685: Reduced, Prostaglandins, ovary
282 decreased intracellular cholesterol transport (GO:0032367) cholesterol (CHEBI:16113) 644: Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
290 decreased dopamine beta-monooxygenase activity (GO:0004500) dopamine beta-hydroxylase (PR:000006294) 526: Inhibition, Inhibition of Dopamine-beta-hydroxylase
281 decreased lipoprotein transport (GO:0042953) lipoprotein (CHEBI:6495) 643: Decreased Cholesterol, Decreased Uptake of Lipoproteins
262 decreased ovulation (GO:0030728) 488: Decrease, Ovulation