Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 76 to 100 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
728 increased gene expression (GO:0010467) teratocarcinoma-derived growth factor 1 (PR:000030513) None
721 increased DNA molecule region (FMA:84119) None
712 decreased abnormal circulating hormone level (MP:0005418) 3,3',5-triiodo-L-thyronine (CHEBI:18258) None
775 decreased protein secretion (GO:0009306) None
730 decreased activin receptor signaling pathway (GO:0032924) activin receptor complex (GO:0048179) None
103 disrupted protein dimerization activity (GO:0046983) aryl hydrocarbon receptor nuclear translocator (PR:000004303) None
474 decreased epithelial cell apoptotic process (GO:1904019) None
769 increased neuropilin binding (GO:0038191) None
768 increased protease binding (GO:0002020) None
86 decreased glutathione (CHEBI:16856) None
87 occurrence oxidative stress (MP:0003674) None
792 decreased epithelial cilium movement (GO:0003351) None
789 decreased transcription, DNA-templated (GO:0006351) None
786 decreased pattern recognition receptor signaling pathway (GO:0002221) RNA viral genome (GO:0019022) None
793 decreased regulation of cilium movement (GO:0003352) None
809 decreased cftr isoform 1 (PR:000001045) None
104 morphological change developmental process (GO:0032502) cardiovascular system (UBERON:0004535) None
814 decreased angiotensin-converting enzyme 2 (PR:000003622) None
801 decreased Abnormal ciliary motility (HP:0012262) motile cilium (GO:0031514) None
875 occurrence membrane fusion (GO:0061025) host cell membrane (GO:0033644) None
821 increased synaptic transmission, glutamatergic (GO:0035249) None
840 increased luteinizing hormone signaling pathway (GO:0042700) None
828 increased Increased inflammatory response (HP:0012649) tumor necrosis factor alpha (PR:000000134) None
102 disrupted protein dimerization activity (GO:0046983) aryl hydrocarbon receptor (PR:000003858) None
844 increased StAR-related lipid transfer protein 4 (human) (PR:Q96DR4) None