Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 76 to 100 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
313 increased Stress, Physiological (MESH:D013312)
283 decreased steroid biosynthetic process (GO:0006694) 640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
267 decreased sperm quantity (VT:0002673) 520: Decreased sperm quantity or quality in the adult, Decreased fertility
79 increased respiratory distress (MP:0001954) 445: Respiratory distress/arrest
80 increased ataxia (MP:0001393)
81 increased hyperactivity (MP:0001399)
82 increased paralysis (MP:0000753)
83 decreased population growth rate (PCO:0000008)
145 increased heme oxidation (GO:0006788) 213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)
85 disrupted protein domain specific binding (GO:0019904) 158: N/A, Interferences with SH-/selen-proteins
159 decreased Decreased liver function (HP:0001410) 164: Induction, Liver “Dysfunctional” Changes by CGA 330050
87 occurrence oxidative stress (MP:0003674) None
88 increased neuron death in response to oxidative stress (GO:0036475) 191: Neuronal dysfunction
231 abnormal sex ratio (MESH:D012744) 417: skewed, sex ratio
113 decreased oocyte development (GO:0048599) 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
1146 increased Hepatic bridging fibrosis (HP:0012852) 2414: COL3A1 Signaling Pathway
264 decreased reproductive process (GO:0022414) 675: Reduced, Reproductive Success
109 decreased egg quantity (VT:1000294)
303 increased colony collapse (MESH:D056631)
141 abnormal reproductive behavior (GO:0019098) 363: Altered, Reproductive behaviour
306 decreased reproductive behavior (GO:0019098) 565: Reduced, Brood care
298 abnormal sperm entry (GO:0035037) 535: Abnormal, Sperm penetration (polyspermy)
142 abnormal larval development (GO:0002164)
307 abnormal thermoregulation behavior (NBO:0000051) 568: impaired, Hive thermoregulation
309 premature aging (GO:0007568) 571: Accelerated, Aging