Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1026 to 1050 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1132 decreased cell activation (GO:0001775) fibroblast growth factor 2 (PR:000007489) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1133 disrupted external genitalia morphogenesis (GO:0035261) prepuce (UBERON:0011374) 2400: Preputial epithelial morphogenesis, disrupted
1134 delayed delayed balanopreputial separation (MP:0008940) prepuce of penis (UBERON:0001332) 2401: Male preputial separation, failed/delayed
1135 arrested delayed balanopreputial separation (MP:0008940) prepuce of penis (UBERON:0001332) 2401: Male preputial separation, failed/delayed
1137 increased regulation of steroid hormone biosynthetic process (GO:0090030) 17beta-estradiol (CHEBI:16469) 2402: Increased, estradiol (E2) production in ovaries
1138 increased neurotransmitter secretion (GO:0007269) Metastin (CHEBI:80304) 1985: Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV)
1139 increased increased circulating estradiol level (MP:0005182) 17beta-estradiol (CHEBI:16469) 2294: Plasma estradiol, increased
1140 increased increased uterus weight (MP:0004904) body of uterus (UBERON:0009853) 2413: Increased, uterine weight
1141 increased abnormal reproductive system development (MP:0003936) reproductive organ (UBERON:0003133) 2415: Precocious puberty
1144 increased female sex determination (GO:0030237) population of organisms (PCO:0000001) 2418: Increased, phenotypic female-biased sex ratio
1145 increased female gonad development (GO:0008585) immature gonad (UBERON:2005272) 2417: Increased, differentiation to ovaries
1146 increased Hepatic bridging fibrosis (HP:0012852) 2414: COL3A1 Signaling Pathway
1147 increased protein oxidation (GO:0018158) 1767: Increase, Protein oxidation
6 functional change mitochondrion (GO:0005739)
15 increased muscle contraction (GO:0006936)
27 decreased ketosis (MESH:D007662)
33 decreased 17beta-estradiol (CHEBI:16469)
34 decreased estrogen biosynthetic process (GO:0006703) 17beta-estradiol (CHEBI:16469)
37 increased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 2 (PR:000011397)
49 decreased GABA-gated chloride ion channel activity (GO:0022851) chloride (CHEBI:17996)
54 decreased calcium ion transport (GO:0006816) calcium ion (CHEBI:39124)
57 increased cell death (GO:0008219)
63 decreased synaptic signaling (GO:0099536)
94 decreased testosterone (CHEBI:17347)
96 decreased androgen receptor activity (GO:0004882) androgen receptor (PR:000004191)